OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press3010.17650/1818-8346-2013-8-2-22-33HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯEfficacy and safety of tyrosine kinase inhibitors (dasatinib, nilotinib) in the treatment of chronic phase chronic myeloid leukemiaЭффективность и безопасность ингибиторов тирозинкиназ 2-го поколения (дазатиниб, нилотиниб) в терапии хронической фазы хронического миелолейкозаLomaiaE. G.ЛомаиаЕ. Г.
Russian Federation
lomelza@gmail.comRomanovaE. G.РомановаЕ. Г.
Russian Federation
SbityakovaE. I.СбитяковаЕ. И.
Russian Federation
ZaritskiyA. Yu.ЗарицкийА. Ю.
Russian Federation
Almazov Federal Heart, Blood and Endocrinology Center, Ministry of Health of RussiaФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздрава РоссииAlmazov Federal Heart, Blood and Endocrinology Center, Ministry of Health of Russia Saint Petersburg Pavlov State Medical University, Ministry of Health of RussiaФГБУ «Федеральный центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздрава России ФГБУ «Санкт-Петербургский государственный медицинский университет им. И.П. Павлова» Минздрава России2205201382223321072014210720142013https://oncohematology.abvpress.ru/ongm/article/view/30

Current treatment options for chronic myeloid leukemia (CML) with imatinib allowed achieving long-term progression-free and overall survival and improved patient quality of life. In cases of imatinib resistance therapy with second-generation tyrosine kinases inhibitors – dasatinib and nilotinib – is also possible. The article represents a literature review evaluating efficacy and toxicity of both drugs and highlighting some of the practical issues of CML treatment after first-line therapy failure.

Современные возможности терапии хронического миелолейкоза (ХМЛ) иматинибом (ИМ) позволили достигнуть длительной беспрогрессивной и общей выживаемости, а также высокого качества жизни пациентов. В случаях развития резистентности к ИМ или его непереносимости в настоящее время возможно также проведение терапии ингибиторами тирозинкиназ 2-го поколения – дазатинибом и нилотинибом. В статье представлен обзор литературы с оценкой эффективности и возможного профиля токсичности обоих препаратов, с освещением наиболее актуальных практических вопросов лечения ХМЛ при неудаче терапии первой линии.

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