OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press2710.17650/1818-8346-2013-8-3-55-59PHARMACOTHERAPYФАРМАКОТЕРАПИЯClinical and biochemical features of some intravenous iron complexesКлинико-биохимические особенности некоторых комплексов железа для внутривенного введенияAbashinS. Yu.АбашинС. Ю.
Russian Federation
sergabash@mail.ruMisyurinaE. N.МисюринаЕ. Н.
Russian Federation
ZhelnovaE. I.ЖелноваЕ. И.
Russian Federation
MisyurinA. V.МисюринА. В.
Russian Federation
Dmitriy Rogachev Federal Research Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава РоссииConsultation and Diagnostic Centre “Genotechnologya”Консультативно-диагностический центр «Генотехнология»Hematological Research Center, Ministry of Health of RussiaФГБУ «Гематологический научный центр» Минздрава России2108201383555921072014210720142013https://oncohematology.abvpress.ru/ongm/article/view/27

Most anemia cases associated with iron deficiency. There are various therapeutic approaches to compensate iron deficiency. In some cases,a rapid restore of body iron is required, which is only possible with intravenous administration. Now a number of intravenous iron preparations are available, and each of them has not only advantages. Considering the drugs side effects, there was a need for drugs with high efficiency, low immunogenicity, and minimal toxicity. One of the decisions was to create preparations based on maltose and isomaltose. Such new intravenous iron preparations are ferric carboxymaltose and iron isomaltoside. Currently, there are no available clinical data that isomaltose and maltose preparations differ significantly with respect to adverse reactions associated with their immunogenicity. Based on study results isomaltose preparations in patients with dextran sensibilization should be used with caution. This is not completely exclude the possibility that both of these drugs can be an immune response trigger with a different specificity than the one on dextran develops. Preparations based on maltose, sucrose and gluconate were neutral in immunoprecipitation assay with dextran-reactive antibodies that determines their preference for patients with dextran sensibilisation. Other important properties of ferric carboxymaltose are: convenience of application and lack of oxidative stress that are determined by the slow iron release.

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