Oncohematology

Онкогематология

1818-83462413-4023

Publishing House ABV Press

264

10.17650/1818-8346-2017-12-4-28-33

HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE

ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ

REACTIVE PLASMACYTOSIS AT THE ONSET OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA. CASE REPORT

РЕАКТИВНЫЙ ПЛАЗМОЦИТОЗ В ДЕБЮТЕ АНГИОИММУНОБЛАСТНОЙ Т-КЛЕТОЧНОЙ ЛИМФОМЫ. КЛИНИЧЕСКИЙ СЛУЧАЙ

Chernova

N. G.

Чернова

Н. Г.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

Наталья Геннадьевна Чернова.

125167 Москва, Новый Зыковский проезд, 4

ngchernova@mail.ru

Sinitsyna

M. N.

Синицына

М. Н.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4

Kovrigina

A. M.

Ковригина

А. М.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4

Sidorova

Y. V.

Сидорова

Ю. В.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4

Galtseva

I. V.

Гальцева

И. В.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4

Mar’ina

S. A.

Марьина

С. А.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4

Dvirnyk

V. N.

Двирнык

В. Н.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4

Zvonkov

E. E.

Звонков

Е. Е.

Russian Federation

4 Novyy Zykovskiy Proezd, Moscow 125167

125167 Москва, Новый Зыковский проезд, 4

National Research Center for Hematology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России

08122017

124

28330802201808022018

2017

https://oncohematology.abvpress.ru/ongm/article/view/264

Angioimmunoblastic T-cell lymphoma is a rare T-cell lymphoproliferative disease with generalized lymphadenopathy, hepatosplenomegaly, intoxication and polyclonal hypergammaglobulinemia. The persistence of plasma cells in peripheral blood can be a manifestation of both tumor and reactive processes. In our article, we described the case of angioimmunoblastic T-cell lymphoma with an increase in the number of peripheral blood plasma cells to 28 %, and in bone marrow to 9 %. The complex diagnostics, including plasma cells immunophenotyping, morphology of the lymph node biopsy and bone marrow samples, made it possible to verify the diagnosis of angioimmunoblastic T-cell lymphoma with polyclonal plasmacytosis.

Ангиоиммунобластная Т-клеточная лимфома – редкое Т-клеточное лимфопролиферативное заболевание, протекающее с генерализованной лимфаденопатией, гепатоспленомегалией, поликлональной гипергаммаглобулинемией и симптомами интоксикации. Персистенция плазматических клеток в периферической крови может быть проявлением как опухолевого, так и реактивного процесса. В статье описан случай ангиоиммунобластной Т-клеточной лимфомы, протекающей с увеличением количества плазматических клеток в периферической крови до 28 %, а в пунктате костного мозга – до 9 %. Проведенная комплексная диагностика, включающая иммунофенотипическое исследование плазматических клеток, морфологическое исследование биоптатов лимфатического узла и костного мозга, позволила верифицировать диагноз ангиоиммунобластной Т-клеточной лимфомы, протекающей с поликлональным плазмоцитозом.

angioimmunoblastic T-cell lymphomareactive plasmacytosisplasma-cell leukemiamultiple myeloma

ангиоиммунобластная Т-клеточная лимфомареактивный плазмоцитозплазмоклеточный лейкозмножественная миелома

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