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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">240</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2017-12-2-39-53</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOPOIETIC STEM CELL TRANSPLANTATION</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК У ПАЦИЕНТОВ С ГЕМОБЛАСТОЗАМИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">SECONDARY SOLID TUMORS IN CHILDREN AFTER ALLOGENEIC HEMATOPOIETIC STEM CELLS TRANSPLANTATION: CASE REPORTS AND LITERATURE REVIEW</article-title><trans-title-group xml:lang="ru"><trans-title>ВТОРИЧНЫЕ СОЛИДНЫЕ ОПУХОЛИ У ДЕТЕЙ ПОСЛЕ АЛЛОГЕННОЙ ТРАНСПЛАНТАЦИИ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК (клинические случаи и обзор литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Skvortsova</surname><given-names>Yu. V.</given-names></name><name xml:lang="ru"><surname>Скворцова</surname><given-names>Ю. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic><bold>Контакты:</bold> Юлия Валериевна Скворцова </italic></p><p><italic><italic>117997 Москва, ул. Саморы Машела, 1</italic></italic></p></bio><email>yuscvo@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Balashov</surname><given-names>D. N.</given-names></name><name xml:lang="ru"><surname>Балашов</surname><given-names>Д. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shelichova</surname><given-names>L. N.</given-names></name><name xml:lang="ru"><surname>Шелихова</surname><given-names>Л. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rudneva</surname><given-names>A. E.</given-names></name><name xml:lang="ru"><surname>Руднева</surname><given-names>А. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tereshchenko</surname><given-names>G. V.</given-names></name><name xml:lang="ru"><surname>Терещенко</surname><given-names>Г. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Skorobogatova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Скоробогатова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>117, Leninskiy Prospect, Moscow, 119571</italic></p></bio><bio xml:lang="ru"><p><italic>119571 Москва, Ленинский просп., 117</italic></p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kondratenko</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Кондратенко</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>117, Leninskiy Prospect, Moscow, 119571</italic></p></bio><bio xml:lang="ru"><p><italic>119571 Москва, Ленинский просп., 117</italic></p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vachlyarskaya</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Вахлярская</surname><given-names>С. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>117, Leninskiy Prospect, Moscow, 119571</italic></p></bio><bio xml:lang="ru"><p><italic>119571 Москва, Ленинский просп., 117</italic></p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Borodina</surname><given-names>I. D.</given-names></name><name xml:lang="ru"><surname>Бородина</surname><given-names>И. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bologov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Бологов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>117, Leninskiy Prospect, Moscow, 119571</italic></p></bio><bio xml:lang="ru"><p><italic>119571 Москва, Ленинский просп., 117</italic></p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rumyantsev</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Румянцев</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Samochatova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Самочатова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>1, Samory Mashela Str., Moscow, 117997</italic></p></bio><bio xml:lang="ru"><p><italic>117997 Москва, ул. Саморы Машела, 1</italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Children Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российская детская клиническая больница» Минздрава России, Россия</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-06-27" publication-format="electronic"><day>27</day><month>06</month><year>2017</year></pub-date><volume>12</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>39</fpage><lpage>53</lpage><history><date date-type="received" iso-8601-date="2017-06-27"><day>27</day><month>06</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-06-27"><day>27</day><month>06</month><year>2017</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/240">https://oncohematology.abvpress.ru/ongm/article/view/240</self-uri><abstract xml:lang="en"><p>Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective approach to cure numerous malignant and nonmalignant diseases. This method is more available now, respectively the number of survivors – recipients of HSCT increases every year. Among long-term complications of HSCT secondary solid cancers are one of the most life-threatening. We discuss different types of secondary solid tumours after HSCT and describe international recommendations of their screening and diagnostic. Several case reports from the single center could illustrate these serious late effects. </p></abstract><trans-abstract xml:lang="ru"><p>Аллогенная трансплантация гемопоэтических стволовых клеток (ТГСК) является эффективным методом излечения многих злокачественных и незлокачественных заболеваний. В связи с возрастанием доступности этого метода терапии с каждым годом увеличивается и количество реципиентов ТГСК с поздними осложнениями, среди которых вторичные неоплазии являются одними из наиболее угрожающих. Мы приводим характеристики различных видов вторичных солидных опухолей после аллогенной ТГСК и международные рекомендации по их скринингу и диагностике. Несколько клинических случаев нашего центра позволяют проиллюстрировать поздние эффекты аллогенной ТГСК. </p></trans-abstract><kwd-group xml:lang="en"><kwd>allogeneic hematopoietic stem cell transplantation</kwd><kwd>late effects</kwd><kwd>secondary solid tumours</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллогенная трансплантация гемопоэтических стволовых клеток</kwd><kwd>поздние эффекты</kwd><kwd>вторичные солидные опухоли</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Inamoto Y., Shah N.N., Savani B.N. et al. Secondary solid cancer screening following hematopoietic cell transplantation. Bone Marrow Transplant 2015,50(8):1013–23. 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