OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press23210.17650/1818-8346-2017-12-1-62-70BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕPhysiology and pathology of extracellular vesiculesФизиология и патология внеклеточных везикулPanteleevM. A.ПантелеевМ. А.
Russian Federation

1 Samory Mashela St., Moscow, Russia, 117997;

38A-1 Leninsky Avenue, Moscow 119991, Russia;

Faculty of Physics1-2 Leniskie Gory, Moscow 119991, Russia;

Department of Biological and Medical Physics9 Institutskiy Lane, Dolgoprudny, Moscow Region 141700, Russia

Россия, 117997 Москва, ул. Саморы Машела, 1;

Россия, 119991 Москва, Ленинский просп., 38А, корп. 1;

физический факультет Россия, 119991 Москва, Ленинские горы, 1, стр. 2;

факультет биологической и медицинской физикиРоссия, 141700 Московская обл., г. Долгопрудный, Институтский пер., 9 

mapanteleev@yandex.ruAbaevaA. A.АбаеваА. А.
Russian Federation

38A-1 Leninsky Avenue, Moscow 119991, Russia;

Россия, 119991 Москва, Ленинский просп., 38А, корп. 1;

NechipurenkoD. Yu.НечипуренкоД. Ю.
Russian Federation

1 Samory Mashela St., Moscow, Russia, 117997;

38A-1 Leninsky Avenue, Moscow 119991, Russia;

Faculty of Physics1-2 Leniskie Gory, Moscow 119991, Russia;

Россия, 117997 Москва, ул. Саморы Машела, 1;

Россия, 119991 Москва, Ленинский просп., 38А, корп. 1;

физический факультет Россия, 119991 Москва, Ленинские горы, 1, стр. 2;

ObydenniyS. I.ОбыденныйС. И.
Russian Federation

1 Samory Mashela St., Moscow, Russia, 117997;

38A-1 Leninsky Avenue, Moscow 119991, Russia;

Россия, 117997 Москва, ул. Саморы Машела, 1;

Россия, 119991 Москва, Ленинский просп., 38А, корп. 1;

SveshnikovaA. N.СвешниковаА. Н.
Russian Federation

1 Samory Mashela St., Moscow, Russia, 117997;

38A-1 Leninsky Avenue, Moscow 119991, Russia;

Faculty of Physics1-2 Leniskie Gory, Moscow 119991, Russia;

Россия, 117997 Москва, ул. Саморы Машела, 1;

Россия, 119991 Москва, Ленинский просп., 38А, корп. 1;

физический факультет Россия, 119991 Москва, Ленинские горы, 1, стр. 2;

ShibekoA. M.ШибекоА. М.
Russian Federation

38A-1 Leninsky Avenue, Moscow 119991, Russia;

Россия, 119991 Москва, Ленинский просп., 38А, корп. 1;

National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of RussiaФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииCenter for Theoretical Problems of Physico-Chemical Pharmacology RASФГБУН «Центр теоретических проблем физико-химической фармакологии РАН»Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»Moscow Institute of Physics and Technology (State University)ФГАУО ВО «Московский физико-технический институт (государственный университет)»2604201712162702604201726042017https://oncohematology.abvpress.ru/ongm/article/view/232

This year marks the 50th anniversary of the first publication about blood plasma microparticles. Initially considered as cell fragments or “platelet dust”, extracellular vesicles currently attracted the attention of biochemists, biophysicists, physicians, pharmacists around the world. They are heterogeneous in structure and derived from many cell types, express different antigen and contain variety of biomolecules that determines wide range of biological activity, including procoagulant, regenerative, immunomodulating, and others. They play an important role in the pathophysiology of different diseases and conditions – from infarction, injuries and pregnancies to the “graft versus host” disease. The vesicles as medicaments and their carriers, as well as the drugs that affect them, are a rapidly developing field of research.

Этот год юбилейный: 50 лет назад была опубликована первая работа, сообщающая об открытии микровезикул плазмы крови.Изначально считавшиеся просто обломками клеток, «тромбоцитарной пылью», внеклеточные везикулы в настоящее время привлекают внимание биохимиков, биофизиков, врачей, фармакологов всего мира. Они гетерогенны по устройству и клеточному происхождению, несут на себе и в себе разнообразные биомолекулы и обладают широким спектром биологических активностей (прокоагулянтную, регенеративную, иммуномодулирующую и др.), которые играют важную роль в патофизиологии широкого круга заболеваний и состояний – от инфаркта, травмы и беременности до реакции «трансплантат против хозяина». Сами везикулы в качестве лекарств и их носителей, равно как и влияющие на них препараты, представляют собой объект исследований и разработок, который быстро набирает популярность. Настоящий обзор посвящен современным представлениям о внеклеточных везикулах и их практическом применении.

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