OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press22910.17650/1818-8346-2017-12-1-33-43HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯHow to use ibrutinibКак применять ибрутинибNikitinЕ. А.НикитинЕ. А.
Russian Federation

5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;

Россия, 125284 Москва, 2-й Боткинский проезд, 5;

eugene_nikitin@mail.ruVorobievV. I.ВоробьевВ. И.
Russian Federation

5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;

Россия, 125284 Москва, 2-й Боткинский проезд, 5;

PanteleevМ. А.ПантелеевМ. А.
Russian Federation

1 Samory Mashela St., Moscow 117997, Russia;

Лаборатория клеточного гемостаза и тромбоза

Россия, 117997 Москва, ул. Саморы Машела, 1;

GendlinG. E.ГендлинГ. Е.
Russian Federation

1 Ostrovityanova St., Moscow 117997, Russia

Кафедра госпитальной терапии № 2

Россия, 117997 Москва, ул. Островитянова, 1

PtushkinV. V.ПтушкинВ. В.
Russian Federation

5, 2nd Botkinskiy Proezd, Moscow 125284, Russia;

Россия, 125284 Москва, 2-й Боткинский проезд, 5;

S.P. Botkin City Clinical Hospital, Moscow Heаlthcare DepartmentГБУЗ г. Москвы «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of RussiaФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава Россииru26042017201712133432604201726042017Received:26042017Accepted:26042017Published:26042017https://oncohematology.abvpress.ru/ongm/article/view/229

The emergence of new targeted drugs, affecting B-cell receptor signaling pathway opens a new page in the treatment of chronic lymphocytic leukemia (CLL). It is not simply expanding choice, it will likely to change total strategy of CLL management. Clinical trials have shown improvement of overall survival in CLL patients in both first line and relapsed disease settings. Targeted drugs lack typical complications of chemotherapy, such as myelosupression. However, they have their specific side effects that require particular attention to avoid unjustified dose reduction and treatment cessation. The present review focuses on practical use of ibrutinib, the first inhibitor of Bruton’s tyrosinkinase.

Появление таргетных препаратов открывает новую страницу в лечении больных хроническим лимфолейкозом (ХЛЛ). Это означает не только расширение терапевтического выбора, но и, возможно, изменение всей тактики ведения ХЛЛ в ближайшем будущем. В клинических исследованиях ибрутиниба впервые показано увеличение продолжительности жизни у больных с рефрактерным ХЛЛ по сравнению с данными исторического контроля, а затем и в рандомизированном сравнении с офатумумабом.Таргетным препаратам не свойственны типичные осложнения химиотерапии, такие как миелосупрессия. Тем не менее таргетные препараты имеют свои осложнения. Неумелое использование может привести к преждевременному прекращению приема или редукции доз, что скажется на успехе лечения.Данный обзор посвящен практике применения ибрутиниба – первого в своем классе ингибитора сигнального пути В-клеточного рецептора

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