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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">214</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2016-11-4-32-48</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">IKZF1 DELETIONS ARE INDEPENDENT PROGNOSTIC FACTOR IN PEDIATRIC B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA</article-title><trans-title-group xml:lang="ru"><trans-title>ДЕЛЕЦИИ ГЕНА IKZF1 – НЕЗАВИСИМЫЙ ПРОГНОСТИЧЕСКИЙ ФАКТОР У ДЕТЕЙ С ОСТРЫМ ЛИМФОБЛАСТНЫМ ЛЕЙКОЗОМ ИЗ B-ЛИНЕЙНЫХ ПРЕДШЕСТВЕННИКОВ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tsaur</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Цаур</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>32 Serafimy Deryabinoy St., Ekaterinburg 620149, Russia; 22a Karla Marksa St., Ekaterinburg 620026, Russia; 19 Mira St., Ekaterinburg 620002, Russia; 3 Repina St., Ekaterinburg 620030, Russ</p></bio><bio xml:lang="ru"><p>Григорий Анатольевич Цаур.</p><p>620149 Екатеринбург, ул. Серафимы Дерябиной, 32;  620026 Екатеринбург, ул. Карла Маркса, 22а; Р620002 Екатеринбург, ул. Мира, 19; 620030 Екатеринбург, ул. Репина, 3; tsaur@mail.ru</p></bio><email>tsaur@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Druy</surname><given-names>A. Е.</given-names></name><name xml:lang="ru"><surname>Друй</surname><given-names>А. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>22a Karla Marksa St., Ekaterinburg 620026, Russia; 1 Samory Mashela St., Moscow 117997, Russia</p></bio><bio xml:lang="ru"><p>620026 Екатеринбург, ул. Карла Маркса, 22а; 117997 Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Solodonikov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Солодовников</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>22a Karla Marksa St., Ekaterinburg 620026, Russia; 3 Repina St., Ekaterinburg 620030, Russi</p></bio><bio xml:lang="ru"><p>620026 Екатеринбург, ул. Карла Маркса, 22а</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow 117997, Russia</p></bio><bio xml:lang="ru"><p>117997 Москва, ул. Саморы Машела, 1</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shapochnik</surname><given-names>A. P.</given-names></name><name xml:lang="ru"><surname>Шапочник</surname><given-names>А. 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А.</given-names></name><name xml:lang="ru"><surname>Власова</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>32 Serafimy Deryabinoy St., Ekaterinburg 620149, Russia</p></bio><bio xml:lang="ru"><p>620149 Екатеринбург, ул. Серафимы Дерябиной, 32;</p></bio><xref ref-type="aff" rid="aff16"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Riger</surname><given-names>Т. О.</given-names></name><name xml:lang="ru"><surname>Ригер</surname><given-names>Т. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>32 Serafimy Deryabinoy St., Ekaterinburg 620149, Russia; 22a Karla Marksa St., Ekaterinburg 620026, Russia</p></bio><bio xml:lang="ru"><p>620149 Екатеринбург, ул. Серафимы Дерябиной, 32;  620026 Екатеринбург, ул. Карла Маркса, 22а</p></bio><xref ref-type="aff" rid="aff9"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Verzhbitskaya</surname><given-names>T. Yu.</given-names></name><name xml:lang="ru"><surname>Вержбицкая</surname><given-names>Т. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>32 Serafimy Deryabinoy St., Ekaterinburg 620149, Russia; 22a Karla Marksa St., Ekaterinburg 620026, Russia</p></bio><bio xml:lang="ru"><p>620149 Екатеринбург, ул. Серафимы Дерябиной, 32;  620026 Екатеринбург, ул. Карла Маркса, 22а</p></bio><xref ref-type="aff" rid="aff9"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Olshanskaya</surname><given-names>Yu. V.</given-names></name><name xml:lang="ru"><surname>Ольшанская</surname><given-names>Ю. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow 117997, Russia</p></bio><bio xml:lang="ru"><p>117997 Москва, ул. Саморы Машела, 1</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shorikov</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Шориков</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1/9 4th Dobryninskiy Pereulok, Moscow 119049, Russia</p></bio><bio xml:lang="ru"><p>119049 Москва, 4-й Добрынинский переулок, 1/9</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Arakaev</surname><given-names>О. R.</given-names></name><name xml:lang="ru"><surname>Аракаев</surname><given-names>О. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>32 Serafimy Deryabinoy St., Ekaterinburg 620149, Russia; 22a Karla Marksa St., Ekaterinburg 620026, Russia</p></bio><bio xml:lang="ru"><p> 620149 Екатеринбург, ул. Серафимы Дерябиной, 32; 620026 Екатеринбург, ул. Карла Маркса, 22а</p></bio><xref ref-type="aff" rid="aff9"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Saveliev</surname><given-names>L. I.</given-names></name><name xml:lang="ru"><surname>Савельев</surname><given-names>Л. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>32 Serafimy Deryabinoy St., Ekaterinburg 620149, Russia; 22a Karla Marksa St., Ekaterinburg 620026, Russia; 3 Repina St., Ekaterinburg 620030, Russia</p></bio><bio xml:lang="ru"><p>620149 Екатеринбург, ул. Серафимы Дерябиной, 32;  620026 Екатеринбург, ул. Карла Маркса, 22а; 620030 Екатеринбург, ул. Репина, 3</p></bio><xref ref-type="aff" rid="aff9"/><xref ref-type="aff" rid="aff14"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fechina</surname><given-names>L. G.</given-names></name><name xml:lang="ru"><surname>Фечина</surname><given-names>Л. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>32 Serafimy Deryabinoy St., Ekaterinburg 620149, Russia</p></bio><bio xml:lang="ru"><p>620149 Екатеринбург, ул. Серафимы Дерябиной, 32</p></bio><xref ref-type="aff" rid="aff16"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Regional Children’s Clinical Hospital No 1</institution></aff><aff><institution xml:lang="ru">Областная детская клиническая больница № 1</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Research Institute of Medical Cell Technologies</institution></aff><aff><institution xml:lang="ru">Институт медицинских клеточных технологий</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Ural Federal University named after the First President of Russia B.N. Yeltsin</institution></aff><aff><institution xml:lang="ru">Уральский федеральный университет имени первого Президента России Б.Н. Ельцина</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Ural State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Уральский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev</institution></aff><aff><institution xml:lang="ru">Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Ural State Medical University</institution></aff><aff><institution xml:lang="ru">Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev</institution></aff><aff><institution xml:lang="ru">Оренбургский областной клинический онкологический диспансер</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">Orenburg Regional Clinical Oncological Dispensary</institution></aff><aff><institution xml:lang="ru">Областная детская клиническая больница № 1</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="en">Regional Children’s Clinical Hospital No 1</institution></aff><aff><institution xml:lang="ru">Институт медицинских клеточных технологий</institution></aff></aff-alternatives><aff-alternatives id="aff10"><aff><institution xml:lang="en">Research Institute of Medical Cell Technologies</institution></aff><aff><institution xml:lang="ru">Областная детская клиническая больница № 1</institution></aff></aff-alternatives><aff-alternatives id="aff11"><aff><institution xml:lang="en">Research Institute of Medical Cell Technologies</institution></aff><aff><institution xml:lang="ru">Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева</institution></aff></aff-alternatives><aff-alternatives id="aff12"><aff><institution xml:lang="en">Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev</institution></aff><aff><institution xml:lang="ru">Морозовская детская городская клиническая больница Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><aff-alternatives id="aff13"><aff><institution xml:lang="en">Morozov Pediatric City Clinical Hospital, Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">Областная детская клиническая больница № 1</institution></aff></aff-alternatives><aff-alternatives id="aff14"><aff><institution xml:lang="en">Research Institute of Medical Cell Technologies</institution></aff><aff><institution xml:lang="ru">Уральский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff15"><aff><institution xml:lang="en">Ural State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Областная детская клиническая больница № 1</institution></aff></aff-alternatives><aff id="aff16"><institution>Regional Children’s Clinical Hospital No 1</institution></aff><pub-date date-type="pub" iso-8601-date="2016-12-03" publication-format="electronic"><day>03</day><month>12</month><year>2016</year></pub-date><volume>11</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>32</fpage><lpage>48</lpage><history><date date-type="received" iso-8601-date="2017-01-03"><day>03</day><month>01</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-01-03"><day>03</day><month>01</month><year>2017</year></date></history><permissions><copyright-year>2016</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/214">https://oncohematology.abvpress.ru/ongm/article/view/214</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>acute lymphoblastic leukemia</kwd><kwd>children</kwd><kwd>prognosis</kwd><kwd>risk factors</kwd><kwd>IKZF1 deletions</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острый лимфобластный лейкоз</kwd><kwd>дети</kwd><kwd>прогноз</kwd><kwd>факторы риска</kwd><kwd>делеции гена IKZF1</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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