OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press21310.17650/1818-8346-2016-11-4-25-31HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯMOLECULAR BIOLOGICAL CHARACTERISTICS OF ALK-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMAМОЛЕКУЛЯРНО-БИОЛОГИЧЕСКИЕ ХАРАКТЕРИСТИКИ ALK-ПОЗИТИВНОЙ АНАПЛАСТИЧЕСКОЙ КРУПНОКЛЕТОЧНОЙ ЛИМФОМЫChernyshovaE. V.ЧернышоваЕ. В.
Russian Federation

1 Samory Mashela St., Moscow 117997, Russia

117997 Москва, ул. Саморы Машела, 1

AbramovD. S.АбрамовД. С.
Russian Federation

1 Samory Mashela St., Moscow 117997, Russia

Дмитрий Сергеевич Абрамов.

117997 Москва, ул. Саморы Машела, 1,  abramovd_s@bk.ru

abramovd_s@bk.ruKonovalovD. M.КоноваловД. М.
Russian Federation

1 Samory Mashela St., Moscow 117997, Russia

117997 Москва, ул. Саморы Машела, 1

LarinS. S.ЛаринС. С.
Russian Federation

1 Samory Mashela St., Moscow 117997, Russia

117997 Москва, ул. Саморы Машела, 1

MyakovaN. V.МяковаН. В.
Russian Federation

1 Samory Mashela St., Moscow 117997, Russia

117997 Москва, ул. Саморы Машела, 1

Federal Research Сentre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy RogachevФедеральный научно-клинический центр детской гематологии, онкологии и иммунологии имени Дмитрия Рогачева03122016114253103012017030120172016https://oncohematology.abvpress.ru/ongm/article/view/213

ALK-positive anaplastic large cell lymphoma is a heterogeneous group of mature T-cell non-Hodgkin lymphoma, and is characterized by CD30/Ki-1 expression. Recently, value of various prognostic factors is investigated. These include clinical, histological and molecular genetic changes associated with different signaling pathways activation. Some features of the mechanism of action of anaplastic lymphoma kinases and targeted therapies possibilities addressed in this review.

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