OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press20410.17650/1818-8346-2016-11-3-29-39HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯExtranodal NK/T-cell lymphoma: a review of literature and case reportЭкстранодальная NK/Т-клеточная лимфома: обзор литературы, описание клинического случаяChernovaN. G.ЧерноваН. Г.
Russian Federation
ngchernova@mail.ruNareykoM. V.НарейкоМ. В.
Russian Federation
SinitsynaM. N.СиницынаМ. Н.
Russian Federation
SidorovaYu. V.СидороваЮ. В.
Russian Federation
YatsyG. A.ЯцыкГ. А.
Russian Federation
KovriginaA. M.КовригинаА. М.
Russian Federation
ZvonkovE. E.ЗвонковЕ. Е.
Russian Federation
DvirnykV. N.ДвирныкВ. Н.
Russian Federation
Kuz’minaL. A.КузьминаЛ. А.
Russian Federation
ParovichnikovaE. N.ПаровичниковаЕ. Н.
Russian Federation
SavchenkoV. G.СавченкоВ. Г.
Russian Federation
Research Center for Hematology, Ministry of Health of RussiaФГБУ «Гематологический научный центр» Минздрава России1010201611329391010201610102016https://oncohematology.abvpress.ru/ongm/article/view/204

Extranodal NK/T-cell lymphoma – a rare lymphoproliferative disease characterized predominantly by extranodal localization, aggressive course and low efficiency of conventional chemotherapy. Clinical presentation is diverse and depends on tumor lesion localization. In this article, a literature review and case report of patient with generalized extranodal NK/T-cell lymphoma with bone marrow involvement, unusual intracranial tumor localization, tumor leukemization and central nervous system-leukemia were presented. Adequate treatment strategy made it possible to achieve long-term complete remission in a patient with poor prognosis.

Экстранодальная NK/Т-клеточная лимфома – редкое лимфопролиферативное заболевание, характеризующееся преимущественно экстранодальной локализацией, агрессивным течением и низкой эффективностью стандартной химиотерапии. Клиническая картина разнообразна и зависит от локализации очага опухолевого поражения. В статье мы представили обзор литературы и описали случай генерализованной экстранодальной NK/Т-клеточной лимфомы, протекающей с поражением костного мозга, необычной интракраниальной локализацией одного из опухолевых очагов, лейкемизацией опухолевого процесса и нейролейкемией.Правильно выбранная тактика лечения позволила достигнуть продолжительной полной ремиссии у пациента из группы неблагоприятного прогноза.

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