OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press19310.17650/1818-8346-2016-11-2-21-29HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯLineage switch in relapse of acute leukemia with rearrangement of MLL gene (KMT2A). literature review and case reportsСмена линейной дифференцировки в рецидиве острого лейкоза с перестройкой гена MLL (KMT2A). Обзор литературы и описание случаевZerkalenkovaE. A.ЗеркаленковаЕ. А.
Russian Federation
eazerkalenkova@gmail.comIllarionovaO. I.ИлларионоваО. И.
Russian Federation
KazakovaA. N.КазаковаА. Н.
Russian Federation
PonomarevaN. I.ПономареваН. И.
Russian Federation
BaydunL. V.БайдунЛ. В.
Russian Federation
OsipovaE. Yu.ОсиповаЕ. Ю.
Russian Federation
DubrovinaM. E.ДубровинаМ. Э.
Russian Federation
PopovA. M.ПоповА. М.
Russian Federation
KonyukhovaT. V.КонюховаТ. В.
Russian Federation
PlyasunovaS. A.ПлясуноваС. А.
Russian Federation
MyakovaN. V.МяковаН. В.
Russian Federation
MaschanA. A.МасчанА. А.
Russian Federation
OlshanskayaYu. V.ОльшанскаяЮ. В.
Russian Federation
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1ФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева»Россия, 117997, Москва, ул. Саморы Машела, 1Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1Россия, 117997, Москва, ул. Саморы Машела, 1Russian Children Clinical Hospital, 119571 Moscow, Leninskiy pr., 117ФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева»Russian Children Clinical Hospital, 119571 Moscow, Leninskiy pr., 117ФГБУ «Российская детская клиническая больница Минздрава России»Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1Россия, 119571, Москва, Ленинградский проспект, 117Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1Россия, 117997, Москва, ул. Саморы Машела, 1ФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева»0508201611221290408201604082016https://oncohematology.abvpress.ru/ongm/article/view/193

Lineage switch is a rare phenomenon in which a transition from lymphoid to myeloid was observed in relapse of acute leukemia, or vice versa. This paper presents the four clinical case reports of acute lymphoblastic leukemia with MLL gene rearrangement (KMT2A) with myeloid phenotype in relapse.

Смена линейной дифференцировки – редкое явление, при котором в рецидиве острого лейкоза наблюдается переход из лимфоидного фенотипа в миелоидный или наоборот. В настоящей работе представлены описания 4 клинических случаев острого лимфобластного лейкоза с перестройкой гена MLL (KMT2A), в рецидиве заболевания продемонстрировавших миелоидный фенотип.

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