OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press19210.17650/1818-8346-2016-11-2-8-20HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯCastleman disease (literature review)Болезнь Кастлемана (обзор литературы)MelikyanA. L.МеликянА. Л.
Russian Federation
anoblood@mail.ruEgorovaE. K.ЕгороваЕ. К.
Russian Federation
National Research Center for Hematology, Ministry of Health of RussiaФГБУ «Гематологический научный центр» Минздрава России4 Novyy Zykovskiy Proezd, Moscow, 125167, RussiaРоссия, 125167, Москва, Новый Зыковский проезд, 4а050820161128200408201604082016https://oncohematology.abvpress.ru/ongm/article/view/192

Castleman disease (angiofollicular hyperplasia of lymph nodes) – a rare benign lymphoproliferative disease with prolonged asymptomatic course, associated with a wide variety of autoimmune and oncological diseases and the risk of non-Hodgkin’s lymphoma. The rare occurrence of this disease and a variety of clinical course did not allow for a complete and consistent research on the etiology and pathogenesis and the standard therapies development. In recent years, the number of patients with Castleman disease in the Russian Federation has increased, which requires its recognition among non-neoplastic and neoplastic lymphadenopathy. The article provides an overview about clinical and histological variants of Castleman’s disease, its pathogenesis concepts, classification and treatment.

Болезнь Кастлемана (ангиофолликулярная гиперплазия лимфатических узлов) – редкое доброкачественное лимфопролиферативное заболевание с длительным бессимптомным течением, ассоциированное с широким спектром аутоиммунных и онкологических заболеваний и риском развития неходжкинской лимфомы. Редкая встречаемость данного заболевания и разнообразие клинического течения не позволяют провести полноценные и последовательные исследования по изучению его этиологии и патогенеза, разработать стандартные методы терапии. В последние годы число пациентов с болезнью Кастлемана в Российской Федерации увеличилось, и это требует ее распознавания среди неопухолевых и опухолевых лимфаденопатий. Статья посвящена обзору данных о клинических и гистологических вариантах болезни Кастлемана, концепциях ее патогенеза, классификации и лечения.

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