OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press16410.17650/1818-8346-2015-10-4-25-33HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯGlomerulonephritis associated with marginal zone B-cell lymphoma: clinical, pathological characteristics of renal injury and treatment (clinical cases)Гломерулонефрит, ассоциированный с В-клеточной лимфомой маргинальной зоны: клиническая, патоморфологическая характеристика поражения почек и лечение (клинические случаи)DzhumabaevaB. T.ДжумабаеваБ. Т.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow, 125167

125167, Москва, Новый Зыковский проезд, 4

bola.blood@yandex.ruBirukovaL. S.БирюковаЛ. С.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow, 125167

125167, Москва, Новый Зыковский проезд, 4

GolitsynaE. P.ГолицынаЕ. П.
Russian Federation

8 Bldg. 2 Trubetskaya St., Moscow, 119991

кафедра патологической анатомии, 

119991, Москва, ул. Трубецкая, 8, стр. 2

VarshavskiyV. A.ВаршавскийВ. А.
Russian Federation

8 Bldg. 2 Trubetskaya St., Moscow, 119991

кафедра патологической анатомии, 

119991, Москва, ул. Трубецкая, 8, стр. 2

JulhakyanU. L.ДжулакянУ. Л.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow, 125167

125167, Москва, Новый Зыковский проезд, 4

RoshchinaL. S.РощинаЛ. С.
Russian Federation

4 Novyy Zykovskiy Proezd, Moscow, 125167

125167, Москва, Новый Зыковский проезд, 4

National Research Center for Hematology, Ministry of Health of RussiaФГБУ «Гематологический научный центр» Минздрава РоссииDepartment of Pathological Anatomy, I.M. Sechenov First Moscow State Medical UniversityГБОУ ВПО «Первый МГМУ им. И.М. Сеченова» Минздрава России2312201510425332312201523122015https://oncohematology.abvpress.ru/ongm/article/view/164

Glomerulonephritis associated with marginal zone B-cell lymphoma at the onset of disease is rarely diagnosed. In this article we reported two patient of the extranodal marginal zone B-cell lymphoma with kidney damage. The first patient with the extranodal marginal zone B-cell lymphoma involved the stomach, lymph nodes, bone marrow and associated with mesangioproliferative glomerulonephritis and renal failure. The second patient with the splenic form of marginal zone B-cell lymphoma associated with fibrillary glomerulonephritis and hepatitis C and involve the lymph nodes, liver, bone marrow, and synthesis monoclonal immunoglobulin (IgMκ), cryoglobulin type II. Glomerulonephritis of the both cases were established on the renal biopsies by the morphological investigation, immunofluorescence, and electron microscopy.

Both patients received therapy with bendamustine and rituximab, which has resulted in complete remission for lymphatic tumors and improve of kidney function. Overall and event-free survival in the first case corresponds to 21 and 16 months, the second 29 and 20, respectively.

These cases illustrates that the kidney may be initially involved by extranodal marginal zone B-cell lymphoma, and the need for expanded investigation of the possible dissemination. Combination of bendamustine and rituximab were effective and safety treatment in these cases.

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