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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">163</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2015-10-4-15-24</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Treatment of B-cells non-Hodgkin lymphomas with combined immunochemotherapy: ability to treatment optimization</article-title><trans-title-group xml:lang="ru"><trans-title>Лечение зрелоклеточных В-клеточных неходжкинских лимфом с использованием комбинированной иммунохимиотерапии: возможности оптимизации терапевтической стратегии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Smirnova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Смирнова</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Myakova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Мякова</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Belogurova</surname><given-names>M. B.</given-names></name><name xml:lang="ru"><surname>Белогурова</surname><given-names>М. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 Dinamo Prospect, St. Petersburg, 197110</p></bio><bio xml:lang="ru"><p>197110, Санкт-Петербург, пр-т Динамо, 3</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ryskal</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Рыскаль</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>22 Baumana St., Perm, 614066</p></bio><bio xml:lang="ru"><p>614066, Пермь, ул. Баумана, 22</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nikonova</surname><given-names>O. E.</given-names></name><name xml:lang="ru"><surname>Никонова</surname><given-names>О. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>22 Baumana St., Perm, 614066</p></bio><bio xml:lang="ru"><p>614066, Пермь, ул. Баумана, 22</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sharapova</surname><given-names>G. R.</given-names></name><name xml:lang="ru"><surname>Шарапова</surname><given-names>Г. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>30 Severnaya St., Nizhnevartovsk, 628609</p></bio><bio xml:lang="ru"><p>628609, Нижневартовск, ул. Северная, 30</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedorova</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Федорова</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><bio xml:lang="en"><p>43 Frunzenskaya St., Borovlyany Village, Minsk Region, 223053</p></bio><bio xml:lang="ru"><p>223053, Минская область, дер. Боровляны, ул. Фрунзенская, 43</p></bio><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Grigorieva</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Григорьева</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>7 Obvodnyy Kanal Prospect, Archangelsk, 163002</p></bio><bio xml:lang="ru"><p>163002, Архангельск, пр-т Обводный канал, 7</p></bio><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamardina</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Шамардина</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>211 Vaneeva St., N. Novgorod, 603136</p></bio><bio xml:lang="ru"><p>603136, Нижний Новгород, ул. Ванеева, 211</p></bio><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ponomareva</surname><given-names>N. I.</given-names></name><name xml:lang="ru"><surname>Пономарева</surname><given-names>Н. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>117 Leninskiy Prospect, Moscow, 117513</p></bio><bio xml:lang="ru"><p>117513, Москва, Ленинский пр-т, 117</p></bio><xref ref-type="aff" rid="aff8"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Abramov</surname><given-names>D. S.</given-names></name><name xml:lang="ru"><surname>Абрамов</surname><given-names>Д. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Konovalov</surname><given-names>D. M.</given-names></name><name xml:lang="ru"><surname>Коновалов</surname><given-names>Д. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dubrovina</surname><given-names>M. E.</given-names></name><name xml:lang="ru"><surname>Дубровина</surname><given-names>М. Э.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Samochatova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Самочатова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow, 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><email>elena.samochatova@fnkc.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Municipal Clinical Hospital No 31</institution></aff><aff><institution xml:lang="ru">СПб ГБУЗ «Городская клиническая больница № 31»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Perm,  Regional Children Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ГБУЗ ПК «Пермская краевая детская клиническая больница»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Nizhnevartovsk Regional Children Hospital</institution></aff><aff><institution xml:lang="ru">БУ ХМАО – Югры «Нижневартовская окружная клиническая детская больница»</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Republician Center for Pediatric Oncology, Hematology and Immunology, Ministry of Health of Republic of Belarus</institution></aff><aff><institution xml:lang="ru">ГУ «Республиканский научно-практический центр детской онкологии, гематологии и иммунологии» Минздрава Республики Беларусь</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">P.G. Vyzhletsov Archangelsk Regional Children Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ГБУЗ АО «Архангельская областная детская клиническая больница им. П.Г. Выжлецова»</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">N. Novgorod Regional Children Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ГБУЗ НО «Нижегородская областная детская клиническая больница»</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="en">Russian Children Clinical Hospital, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российская детская клиническая больница» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-12-23" publication-format="electronic"><day>23</day><month>12</month><year>2015</year></pub-date><volume>10</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>15</fpage><lpage>24</lpage><history><date date-type="received" iso-8601-date="2015-12-23"><day>23</day><month>12</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-12-23"><day>23</day><month>12</month><year>2015</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/163">https://oncohematology.abvpress.ru/ongm/article/view/163</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>non-Hodgkin</kwd><kwd>s lymphoma</kwd><kwd>children and adolescents</kwd><kwd>targeted therapy</kwd><kwd>rituximab (Mabthera)</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>неходжкинские лимфомы</kwd><kwd>дети и подростки</kwd><kwd>таргетная терапия</kwd><kwd>ритуксимаб (Мабтера)</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">РНПЦ ДОГИ, Минск, Беларусь; Онкодиспансер Московской области, Балашиха; РДКБ, Махачкала; ОДКБ № 1, Екатеринбург; ОДКБ, Иркутск; РДКБ, Москва; ОДКБ, Нижний Новгород; Пермская КДКБ, Пермь; ГКБ № 31, Санкт-Петербург; РДКБ, ­Казань; РДКБ Чебоксары; ОДКБ, Челябинск; АДКБ ­Архангельск; ОКДБ, Нижневартовск; ОДКБ, Рязань; ГБУЗ ОДБ, Брянск; А.Е. Руднева и Ю.В. Румянцева</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Murphy S.B., Bowman W.P., Abromowitch M. et al. Results of treatment of advanced – stage Burkitt, s lymphoma and B-cell (sIg+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated highdose methotrexate and cytarabine. J Clin Oncol 1986;4(12):1732–9.</mixed-citation><mixed-citation xml:lang="ru">Murphy S.B., Bowman W.P., Abromowitch M. et al. Results of treatment of advanced – stage Burkitt, s lymphoma and B-cell (sIg+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated highdose methotrexate and cytarabine. J Clin Oncol 1986;4(12):1732–9.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Patte C., Philip T., Rodary C. et al. 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