OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press16210.17650/1818-8346-2015-10-4-8-14HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯEfficacy of lenalidomide, bortezomib, and prednisolone in patients with relapsed or refractory multiple myelomaЭффективность леналидомида, бортезомиба и преднизолона при лечении пациентов с рецидивирующей и рефрактерной множественной миеломойМitinаT. A.МитинаТ. А.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

mi_69@inbox.ruGolenkovA. K.ГоленковА. К.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

TrifonovaE. V.ТрифоноваЕ. В.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

KataevaE. V.КатаеваЕ. В.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

VysotskayaL. L.ВысоцкаяЛ. Л.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

ChernykhYu. B.ЧерныхЮ. Б.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

ZakharovS. G.СахаровС. Г.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

BelousovK. A.БелоусовК. А.
Russian Federation

61/2 Shchepkina St., Moscow, 129110

129110, Москва, ул. Щепкина, 61/2

KaraulovA. V.КарауловА. В.
Russian Federation

8 Build. 2 Trubetskaya St., Moscow, 119991

119991, Москва, ул. Трубецкая, 8, стр. 2

V.F. Vladimirskiy Moscow Regional Research and Clinical InstituteГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»I.M. Sechenov First Moscow State Medical UniversityГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России231220151048142312201523122015https://oncohematology.abvpress.ru/ongm/article/view/162

49 patients aged 28 to 81 years old (median age of 55 years old) with relapsed or refractory multiple myeloma (MM) were enrolled in the study. The relapse was diagnosed in 25 (51 %) patients, the refractory disease was determined in 24 (49 %) patients (including primary refractory disease in 14 (28.6 %) patients). The prior therapy for all patients included bortezomib-based treatment in combination with thalidomide and autologus stem cell transplantation (8.1 %). Lenalidomide had not been used in the previous therapeutic regimens. All patients were given the original treatment regimen, which included lenalidomide, bortezomib, and prednisolone (RVP). The therapy was made up of seven induction cycles with each one lasting for 48 days. Length of courses was 14 days. After seven cycles of RVP therapy were over, such results were achieved: complete response (CR) in 1 (2 %) patient; very good partial response (VGPR) in 4 (8 %) patients; partial response (PR) in 26 (53 %) patients; minimal response (MR) in 2 (4 %) patients; stable disease (SD) in 8 (16.3 %) patients, and progressive disease (PD) in 8 (16.3 %) patients. The objective response rate, including CR+VGPR+PR, was obtained in 31 (63.1 %) patients. The objective response rate, including MR, was seen in 33 (67.1 %) patients. Hematological and non-hematological toxicities were moderate. Taking into account the above, the RVP therapeutic regimen has demonstrated its efficacy as a second-line therapy for MM, and its clinical use can solve the problem of relapsed/refractory to bortezomib-based regimens MM management.

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