OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press15810.17650/1818-8346-2015-10-3-78-91BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕIntegrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part II. The sensitivity of integral tests to hypercoagulable statesИнтегральные лабораторные тесты гемостаза в диагностике гиперкоагуляции и оценке риска тромбоза. Часть II. Чувствительность интегральных тестов к гиперкоагуляционным состояниямLipetsE. N.ЛипецЕ. Н.
Russian Federation

1 Samory Mashela St., Moscow, 117997;

4 Kosygina St., Moscow, 119991

117997, Москва, ул. Саморы Машела;

119991, Москва, ул. Косыгина, 4

AtaullakhanovF. I.АтауллахановФ. И.
Russian Federation

1 Samory Mashela St., Moscow, 117997;

4 Kosygina St., Moscow, 119991;

4th 8 Marta St., Moscow, 125319;

1 Lеninskie gory St., Moscow, 119991

117997, Москва, ул. Саморы Машела;

119991, Москва, ул. Косыгина, 4;

125319, Москва, 4-я ул. 8 Марта, 3;

119991, Москва, ул. Ленинские горы, 1

PanteleevM. A.ПантелеевМихаил Александрович
Russian Federation

1 Samory Mashela St., Moscow, 117997;

4 Kosygina St., Moscow, 119991;

4th 8 Marta St., Moscow, 125319;

1 Lеninskie gory St., Moscow, 119991

117997, Москва, ул. Саморы Машела;

119991, Москва, ул. Косыгина, 4;

125319, Москва, 4-я ул. 8 Марта, 3;

119991, Москва, ул. Ленинские горы, 1

mapanteleev@yandex.ruFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry RоgachevФНКЦ детской гематологии, онкологии и иммунологии им. Дмитрия РогачеваTheoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of SciencesЦентр теоретических проблем физико-химической фармакологии РАНHemaCore CompanyООО «Гемакор»M.V. Lomonosov Moscow State UniversityМосковский государственный университет им. М.В. Ломоносова0810201510378910810201508102015https://oncohematology.abvpress.ru/ongm/article/view/158

In the second part we present a review of the existing data about ability of integrated tests, as already introduced in clinical practice, and the new (test of thrombin generation, thromboelastography, thrombodynamics, perfusion chamber) to assess the risk of thrombosis in different pathologies. We can conclude that the existing integrated tests can be an important tool in the diagnosis of hypercoagulation. However, lack of standardization prevents their use: various tests and modifications of each test are different in sensitivity and specificity for each pathological condition. Furthermore, even in situations where the tests can reliably identify a group of patients with different degrees of thrombosis risk, their use in clinical practice is often difficult, since the differences between these groups were statistically significant, but the normal range and patients significantly overlap.

В данной работе представлен обзор существующих данных относительно способности интегральных тестов, как уже введенных в клиническую практику, так и новых (тест генерации тромбина, тромбоэластография, тромбодинамика, перфузионные камеры), оценивать риск тромбоза при различных патологиях. Мы пришли к выводу, что существующие интегральные тесты могут стать важным инструментом в диагностике гиперкоагуляции. Однако имеющийся в настоящее время недостаток стандартизации препятствует их применению: различные тесты и любые их модификации различаются по чувствительности и специфичности для каждого патологического состояния. Кроме того, даже в тех ситуациях, когда тесты могут достоверно выявлять группы пациентов с различной степенью риска тромбоза, их применение в клинической практике для принятия решений часто затруднительно, так как различия между такими группами статистически достоверны, однако диапазоны норм и пациентов значительно перекрываются

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