OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press15410.17650/1818-8346-2015-10-3-58-63HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯCardiovascular and metabolic problems associated with application of second generation tyrosine kinase inhibitors in patients with chronic myeloid leukemiaКардиоваскулярные и метаболические проблемы при применении ингибиторов тирозинкиназ 2-го поколения у пациентов с хроническим миелолейкозомVinogradovaO. Y.ВиноградоваОльга Юрьевна
Russian Federation

1 Samory Mashela St., Moscow, 117198;

1 Ostrovityanovа St., Moscow, 117997

117198, Москва, ул. Саморы Машела, 1;

117997, Москва, ул. Островитянова, 1

olgavinz@mail.ruFederal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev, Ministry of Health of RussiaФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Д. Рогачева» Минздрава России“N.I. Pirogov Russian National Research Medical University”, Ministry of Health of RussiaГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России0810201510358630710201507102015https://oncohematology.abvpress.ru/ongm/article/view/154

During therapy with second generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia, a number of patients demonstrate non-hematological toxicity of various degrees. The article contains review of references about second generation tyrosine kinase inhibitors effect on the frequency of cardiovascular and metabolic problems.

При терапии ингибитором тирозинкиназ 2-го поколения хронического миелолейкоза у ряда пациентов наблюдается различной степени негематологическая токсичность. В статье приведен литературный обзор влияния ингибиторов тирозинкиназ 2-го поколения на частоту развития проблем со стороны сердечно-сосудистой системы, углеводного и липидного обмена.

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