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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">150</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2015-10-3-18-27</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Quality of life, symptom profile and clinical efficacy of second-line treatment with dasatinib in patients with imatinib-resistant or -intolerant chronic myeloid leukemia: results of 2-year follow-up</article-title><trans-title-group xml:lang="ru"><trans-title>Показатели качества жизни, профиль симптомов и клинический эффект терапии второй линии дазатинибом у больных хроническим миелолейкозом при резистентности или непереносимости предшествующей терапии иматинибом: результаты 2-летнего мониторинга</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ionova</surname><given-names>T. I.</given-names></name><name xml:lang="ru"><surname>Ионова</surname><given-names>Т. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>70 Nizhnyaya Pervomayskaya St., Moscow, 105203;</p><p>1 Artilleriyskaya St., St. Petersburg, 191014</p></bio><bio xml:lang="ru"><p>105203, Москва, ул. Нижняя Первомайская, 70;</p><p>191014, Санкт-Петербург, ул. Артиллерийская, 1</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nikitina</surname><given-names>T. P.</given-names></name><name xml:lang="ru"><surname>Никитина</surname><given-names>Т. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>70 Nizhnyaya Pervomayskaya St., Moscow, 105203;</p><p>1 Artilleriyskaya St., St. Petersburg, 191014</p></bio><bio xml:lang="ru"><p>105203, Москва, ул. Нижняя Первомайская, 70;</p><p>191014, Санкт-Петербург, ул. Артиллерийская, 1</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lomaia</surname><given-names>E. G.</given-names></name><name xml:lang="ru"><surname>Ломаиа</surname><given-names>Е. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>2 Akkuratova St., St. Petersburg, 197341</p></bio><bio xml:lang="ru"><p>197341, Санкт-Петербург, ул Аккуратова, 2</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kuchma</surname><given-names>G. B.</given-names></name><name xml:lang="ru"><surname>Кучма</surname><given-names>Г. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6 Sovetskaya St., Orenburg, 460000</p></bio><bio xml:lang="ru"><p>460000, Оренбург, ул. Советская, 6</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Machyulaytene</surname><given-names>E. R.</given-names></name><name xml:lang="ru"><surname>Мачюлайтене</surname><given-names>Е. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6/8 L’va Tolstogo St., St. Petersburg, 197022</p></bio><bio xml:lang="ru"><p>197022, Санкт-Петербург, ул. Льва Толстого, 6 / 8</p></bio><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Usacheva</surname><given-names>E. I.</given-names></name><name xml:lang="ru"><surname>Усачёва</surname><given-names>Е. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6/8 L’va Tolstogo St., St. Petersburg, 197022</p></bio><bio xml:lang="ru"><p>197022, Санкт-Петербург, ул. Льва Толстого, 6 / 8</p></bio><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shnaider</surname><given-names>T. V.</given-names></name><name xml:lang="ru"><surname>Шнейдер</surname><given-names>Т. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>45–49 Lunacharskogo Prosp., St. Petersburg, 194291</p></bio><bio xml:lang="ru"><p>194291, Санкт-Петербург, пр. Луначарского, 45–49</p></bio><xref ref-type="aff" rid="aff7"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rodionova</surname><given-names>A. Yu.</given-names></name><name xml:lang="ru"><surname>Родионова</surname><given-names>А. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Artilleriyskaya St., St. Petersburg, 191014</p></bio><bio xml:lang="ru"><p>191014, Санкт-Петербург, ул. Артиллерийская, 1</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurbatova</surname><given-names>K. A.</given-names></name><name xml:lang="ru"><surname>Курбатова</surname><given-names>К. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Artilleriyskaya St., St. Petersburg, 191014</p></bio><bio xml:lang="ru"><p>191014, Санкт-Петербург, ул. Артиллерийская, 1</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pyrogov National Medical-Surgical Center</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медико-хирургический центр им. Н. И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Multinational Center for Quality of Life Research</institution></aff><aff><institution xml:lang="ru">Межнациональный центр исследования качества жизни</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Northwest Federal Medical Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Северо-Западный федеральный медицинский исследовательский центр» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Orenburg State Medical Academy</institution></aff><aff><institution xml:lang="ru">Оренбургская государственная медицинская академия</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Policlinic № 31 of I.P. Pavlov St. Petersburg State Medical University</institution></aff><aff><institution xml:lang="ru">Поликлиника № 31 ГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">R. M. Gorbacheva Memorial Institute of Children Hematology and Transplantation, I.P. Pavlov St. Petersburg State Medical University</institution></aff><aff><institution xml:lang="ru">Институт детской гематологии и трансплантологии им. Р. М. Горбачевой, СПбГМУ им. И. П. Павлова</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Regional Hospital, St. Petersburg</institution></aff><aff><institution xml:lang="ru">Ленинградская областная клиническая больница</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-10-08" publication-format="electronic"><day>08</day><month>10</month><year>2015</year></pub-date><volume>10</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>18</fpage><lpage>27</lpage><history><date date-type="received" iso-8601-date="2015-10-07"><day>07</day><month>10</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-10-07"><day>07</day><month>10</month><year>2015</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/150">https://oncohematology.abvpress.ru/ongm/article/view/150</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>quality of life</kwd><kwd>symptom profile</kwd><kwd>chronic myeloid leukemia</kwd><kwd>dasatinib</kwd><kwd>treatment efficacy</kwd><kwd>safety</kwd><kwd>long-term follow-up</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>качество жизни</kwd><kwd>профиль симптомов</kwd><kwd>хронический миелолейкоз</kwd><kwd>дазатиниб</kwd><kwd>эффект терапии</kwd><kwd>безопасность терапии</kwd><kwd>длительный мониторинг</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">компания «Бристол-Майерс Сквибб»</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Baccarani M., Pileri S., Steegmann J.-L. et al. Chronik myeloid leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 23(7):72–7.</mixed-citation><mixed-citation xml:lang="ru">Baccarani M., Pileri S., Steegmann J.-L. et al. Chronik myeloid leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 23(7):72–7.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Baccarani M., Deininger M.W., Rosti G. et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013;122(6):872–84.</mixed-citation><mixed-citation xml:lang="ru">Baccarani M., Deininger M.W., Rosti G. et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013;122(6):872–84.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Голенков А.К., Высоцкая Л.Л., Трифонова Е.В. и др. Эффективность лечения больных хроническим миелолейкозом иматинибом в широкой клинической практике. Онкогематология 2012;3:17–21. [Golenkov A.K., Vysotskaya L.L., Trifonova E.V. et al. Treatment efficacy of chronic myeloid leukemia with imatinib in clinical pravtice. Onkogematologiya = Oncohematology 2012;3:17–21. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Голенков А.К., Высоцкая Л.Л., Трифонова Е.В. и др. Эффективность лечения больных хроническим миелолейкозом иматинибом в широкой клинической практике. Онкогематология 2012;3:17–21. [Golenkov A.K., Vysotskaya L.L., Trifonova E.V. et al. Treatment efficacy of chronic myeloid leukemia with imatinib in clinical pravtice. Onkogematologiya = Oncohematology 2012;3:17–21. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Практические аспекты терапии хронического миелолейкоза в хронической фазе (по материалам выступлений на Конгрессе гематологов). Москва, 3 июля 2012 г. Онкогематология 2012;3:8–16. [Practical aspects of chronic myeloid leukemia treatment in chronic phase (According to the presentations of the Congress of Hematology. Moscow, July 3, 2012. Onkogematologiya = Oncohematology 2012;3:8–16. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Практические аспекты терапии хронического миелолейкоза в хронической фазе (по материалам выступлений на Конгрессе гематологов). Москва, 3 июля 2012 г. Онкогематология 2012;3:8–16. [Practical aspects of chronic myeloid leukemia treatment in chronic phase (According to the presentations of the Congress of Hematology. Moscow, July 3, 2012. Onkogematologiya = Oncohematology 2012;3:8–16. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Bubnoff N., Duyster J. Chronic myelogenous leukemia treatment and monitoring. Dtsch Arztebl Int 2010;107(7): 114–21.</mixed-citation><mixed-citation xml:lang="ru">Bubnoff N., Duyster J. Chronic myelogenous leukemia treatment and monitoring. Dtsch Arztebl Int 2010;107(7): 114–21.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Quintas-Cardama A., Cortes J.E., O’Brien S. et al. Dasatinib early intervention after cytogenetic or hematologic resistance to imatinib in patients with chronic myeloid leukemia. Cancer 2009:2912–21.</mixed-citation><mixed-citation xml:lang="ru">Quintas-Cardama A., Cortes J.E., O’Brien S. et al. Dasatinib early intervention after cytogenetic or hematologic resistance to imatinib in patients with chronic myeloid leukemia. Cancer 2009:2912–21.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Hochhaus A., Baccarani M., Deininger M. et al. Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia 2008;22(6):1–7.</mixed-citation><mixed-citation xml:lang="ru">Hochhaus A., Baccarani M., Deininger M. et al. Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia 2008;22(6):1–7.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Ottmann O., Dombret H., Martinelli G. et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007;110:2309–15.</mixed-citation><mixed-citation xml:lang="ru">Ottmann O., Dombret H., Martinelli G. et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007;110:2309–15.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Shah N.P., Cortes J.E., Schiffer C.A. et al. Five-year follow-up of patients with imatinib-resistant or -intolerant chronic-phase chronic myeloid leukemia (CML-CP) receiving dasatinib. J Clin Oncol 2011;29:1634–42.</mixed-citation><mixed-citation xml:lang="ru">Shah N.P., Cortes J.E., Schiffer C.A. et al. Five-year follow-up of patients with imatinib-resistant or -intolerant chronic-phase chronic myeloid leukemia (CML-CP) receiving dasatinib. J Clin Oncol 2011;29:1634–42.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Ломаиа Е.Г., Романова Е.Г., Сбитякова Е.И., Зарицкий А.Ю. Эффективность и безопасность ингибиторов тирозинкиназ 2-го поколения (дазатиниб, нилотиниб) в терапии хронической фазы хронического миелолейкоза. Онкогематология 2013;2:22–33. [Lomaia E.G., Romanova E.G., Sbityakova E.I., Zaritskiy A.Yu. Efficacy and safety of tyrosinkinase inhibitors (Dasatinib, Nilotinib) in the treatment of chronic phase chronic myeloid leukemia. Onkogematologiya = Oncohematology 2013;2:22–33. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Ломаиа Е.Г., Романова Е.Г., Сбитякова Е.И., Зарицкий А.Ю. Эффективность и безопасность ингибиторов тирозинкиназ 2-го поколения (дазатиниб, нилотиниб) в терапии хронической фазы хронического миелолейкоза. Онкогематология 2013;2:22–33. [Lomaia E.G., Romanova E.G., Sbityakova E.I., Zaritskiy A.Yu. Efficacy and safety of tyrosinkinase inhibitors (Dasatinib, Nilotinib) in the treatment of chronic phase chronic myeloid leukemia. Onkogematologiya = Oncohematology 2013;2:22–33. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Волкова М.А. Новые возможности в терапии хронического миелолейкоза: дазатиниб. Клиническая онкогематология 2008;1(3):218–25. [Volkova M.A. New possibilities in the treatment of chronic myeloid leukemia: Dasatinib. Klinicheskaya onkogematologiya = Clinical Oncohematology 2008;1(3):218–25. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Волкова М.А. Новые возможности в терапии хронического миелолейкоза: дазатиниб. Клиническая онкогематология 2008;1(3):218–25. [Volkova M.A. New possibilities in the treatment of chronic myeloid leukemia: Dasatinib. Klinicheskaya onkogematologiya = Clinical Oncohematology 2008;1(3):218–25. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Shah N., Kim D., Kantarjian H. et al. Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib. Haematologica 2010;95(2):232–40.</mixed-citation><mixed-citation xml:lang="ru">Shah N., Kim D., Kantarjian H. et al. Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib. Haematologica 2010;95(2):232–40.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Wong S.F. New dosing schedules of dasatinib for CML and adverse event management. J Hematol Oncol 2009;2:10.</mixed-citation><mixed-citation xml:lang="ru">Wong S.F. New dosing schedules of dasatinib for CML and adverse event management. J Hematol Oncol 2009;2:10.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Krauth M., Herndlhofer S., Schmook M. et al. Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily. Haematologica 2011;96(1):163–6.</mixed-citation><mixed-citation xml:lang="ru">Krauth M., Herndlhofer S., Schmook M. et al. Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily. Haematologica 2011;96(1):163–6.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Guidelines. Patient-reported outcomes in hematology. The EHA SWG “Quality of life and symptoms”. Forum Service Editore. Genoa, Forum Service Editore, 2012. 206 p.</mixed-citation><mixed-citation xml:lang="ru">Guidelines. Patient-reported outcomes in hematology. The EHA SWG “Quality of life and symptoms”. Forum Service Editore. Genoa, Forum Service Editore, 2012. 206 p.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Eficace F., Cocks K., Breccia M. et al. Time for a new era in the evaluation of targeted therapies for patients with chronic myeloid leukemia: inclusion of quality of life and other patient-reported outcomes. Crit Rev Oncol Hematol 2012;81:123–35.</mixed-citation><mixed-citation xml:lang="ru">Eficace F., Cocks K., Breccia M. et al. Time for a new era in the evaluation of targeted therapies for patients with chronic myeloid leukemia: inclusion of quality of life and other patient-reported outcomes. Crit Rev Oncol Hematol 2012;81:123–35.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Efficace F., Rosti G., Aaronson N. et al. Patient- versus physician-reporting of symptoms and health status in chronic myeloid leukemia. Haematologica 2014;99(4):788–93.</mixed-citation><mixed-citation xml:lang="ru">Efficace F., Rosti G., Aaronson N. et al. Patient- versus physician-reporting of symptoms and health status in chronic myeloid leukemia. Haematologica 2014;99(4):788–93.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Efficacе F., Cardoni A., Cottone F. et al. Tyrosinekinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review. Leuk Res 2013;37(2): 206–13.</mixed-citation><mixed-citation xml:lang="ru">Efficacе F., Cardoni A., Cottone F. et al. Tyrosinekinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review. Leuk Res 2013;37(2): 206–13.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Baccarani M., Efficace F., Rosti G. Moving towards patient-centered decision-making in chronic myeloid leukemia: assessment of quality of life and symptom burden. Haematologica 2014;99(2):205–8.</mixed-citation><mixed-citation xml:lang="ru">Baccarani M., Efficace F., Rosti G. Moving towards patient-centered decision-making in chronic myeloid leukemia: assessment of quality of life and symptom burden. Haematologica 2014;99(2):205–8.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Челышева Е.Ю., Галактионова А.В., Туркина А.Г. Проблема приверженности терапии хронического миелолейкоза: понять пациента и найти решения. Клиническая онкогематология 2013;6(2):157–65. [Chelysheva E.Yu., Galaktionova A.V., Turkina A.G. The commitment problem in treatment of chronic myeloid leukemia: to understand the patient and to find solutions. Klinicheskaya onkogematologiya = Clinical Oncohematology 2013;6(2):157–65. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Челышева Е.Ю., Галактионова А.В., Туркина А.Г. Проблема приверженности терапии хронического миелолейкоза: понять пациента и найти решения. Клиническая онкогематология 2013;6(2):157–65. [Chelysheva E.Yu., Galaktionova A.V., Turkina A.G. The commitment problem in treatment of chronic myeloid leukemia: to understand the patient and to find solutions. Klinicheskaya onkogematologiya = Clinical Oncohematology 2013;6(2):157–65. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. US Food and Drug Administration. Guidance for industry: patient-reported outcome measures; use in medical product development to support labeling claims Available at: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071975.pdf. Accessed September 8, 2009.</mixed-citation><mixed-citation xml:lang="ru">US Food and Drug Administration. Guidance for industry: patient-reported outcome measures; use in medical product development to support labeling claims Available at: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071975.pdf. Accessed September 8, 2009.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Новик А.А., Ионова Т.И. Руководство по исследованию качества жизни в медицине. 3-е изд. Под ред. акад. РАМН Ю.Л. Шевченко. М., 2012. [Novik A.A., Ionova T.I. Guidelines for quality of life assessment in Medicine. 3rd ed. Ed.: Acad. RAMS Yu.L. Shevchenko. Moscow, 2012. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Новик А.А., Ионова Т.И. Руководство по исследованию качества жизни в медицине. 3-е изд. Под ред. акад. РАМН Ю.Л. Шевченко. М., 2012. [Novik A.A., Ionova T.I. Guidelines for quality of life assessment in Medicine. 3rd ed. Ed.: Acad. RAMS Yu.L. Shevchenko. Moscow, 2012. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Efficace F., Baccarani M., Breccia M. Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population. Blood 2011;118(17):4554–60.</mixed-citation><mixed-citation xml:lang="ru">Efficace F., Baccarani M., Breccia M. Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population. Blood 2011;118(17):4554–60.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Pinilla-Ibarz J., Cortes J., Mauro M.J. Side effects of targeted treatments: сlinicians’ perceptions, patients’ realities. Cancer 2011;117(4):688–97.</mixed-citation><mixed-citation xml:lang="ru">Pinilla-Ibarz J., Cortes J., Mauro M.J. Side effects of targeted treatments: сlinicians’ perceptions, patients’ realities. Cancer 2011;117(4):688–97.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Williams L.A., Gonzales A.G., Ault P. et al. Measuring the symptom burden associated with the treatment of chronic myeloid leukemia. Blood 2013;122(5):641–7.</mixed-citation><mixed-citation xml:lang="ru">Williams L.A., Gonzales A.G., Ault P. et al. Measuring the symptom burden associated with the treatment of chronic myeloid leukemia. Blood 2013;122(5):641–7.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Ionova T., Nikitina T., Gritsenko T. et al. Quality of life and symptom profile in patients with imatinib-resistant or -intolerant chronic myeloid leukemia. Haematologica 2012;97(1):249.</mixed-citation><mixed-citation xml:lang="ru">Ionova T., Nikitina T., Gritsenko T. et al. Quality of life and symptom profile in patients with imatinib-resistant or -intolerant chronic myeloid leukemia. Haematologica 2012;97(1):249.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Ионова Т.И., Федоренко Д.А., Никитина Т.П., Курбатова К.А. Качество жизни и профиль симптомов у больных хроническим миелолейкозом на фоне терапии второй линии дазатинибом при непереносимости и резистентности к иматинибу. Клиническая онкогематология 2013;6(2):166–75. [Ionova T.I., Fedorenko D.A., Nikitina T.P., Kurbatova K.A. Quality of life and symptoms profile in patients with chronic myeloid leukemia during second-line therapy withdasatinib after intolerance and resistance to imatinib. Klinicheskaya onkogematologiya = Clinical Oncohematology 2013;6(2):166–75. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Ионова Т.И., Федоренко Д.А., Никитина Т.П., Курбатова К.А. Качество жизни и профиль симптомов у больных хроническим миелолейкозом на фоне терапии второй линии дазатинибом при непереносимости и резистентности к иматинибу. Клиническая онкогематология 2013;6(2):166–75. [Ionova T.I., Fedorenko D.A., Nikitina T.P., Kurbatova K.A. Quality of life and symptoms profile in patients with chronic myeloid leukemia during second-line therapy withdasatinib after intolerance and resistance to imatinib. Klinicheskaya onkogematologiya = Clinical Oncohematology 2013;6(2):166–75. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Ionova T., Nikitina T., Gritsenko T. et al. Benefits/risks of dasatinib therapy in patients with imatinib-resistant or -intolerant chronic myeloid leukemia: physician’s and patient’s perspective. Haematologica 2013;(Suppl): B1381.</mixed-citation><mixed-citation xml:lang="ru">Ionova T., Nikitina T., Gritsenko T. et al. Benefits/risks of dasatinib therapy in patients with imatinib-resistant or -intolerant chronic myeloid leukemia: physician’s and patient’s perspective. Haematologica 2013;(Suppl): B1381.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Ionova T.I., Nikitina T.P., Gritsenko T.A. et al. The value of dasatinib therapy in patients with imatinib-resistant or -intolerant chronic myeloid leukemia from physician’s and patient’s perspective: “real world” outcomes. Haematologica 2014;(Suppl):B1675.</mixed-citation><mixed-citation xml:lang="ru">Ionova T.I., Nikitina T.P., Gritsenko T.A. et al. The value of dasatinib therapy in patients with imatinib-resistant or -intolerant chronic myeloid leukemia from physician’s and patient’s perspective: “real world” outcomes. Haematologica 2014;(Suppl):B1675.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Nikitina T.P., Fedorenko D.A., Kurbatova K.A. et al. Baseline Quality of Life in Chronic Phase Chronic Myeloid Leukemia Patients with Resistance or Intolerance to Imatinib and its Potential Prognostic Value. ELN Frontiers meeting. Abstr. 2014. P21.</mixed-citation><mixed-citation xml:lang="ru">Nikitina T.P., Fedorenko D.A., Kurbatova K.A. et al. Baseline Quality of Life in Chronic Phase Chronic Myeloid Leukemia Patients with Resistance or Intolerance to Imatinib and its Potential Prognostic Value. ELN Frontiers meeting. Abstr. 2014. P21.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Ionova T.I., Nikitina T.P., Fedorenko D.A. et al. Long-Term Outcomes of Dasatinib Therapy in Patients with Imatinib-Resistant or -Intolerant Chronic Myeloid Leukemia from Physician’s and Patient’s Perspective. Blood 2014;124(21):А2644.</mixed-citation><mixed-citation xml:lang="ru">Ionova T.I., Nikitina T.P., Fedorenko D.A. et al. Long-Term Outcomes of Dasatinib Therapy in Patients with Imatinib-Resistant or -Intolerant Chronic Myeloid Leukemia from Physician’s and Patient’s Perspective. Blood 2014;124(21):А2644.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Kropf P., Barnes G., Tang B.. et al. Burden of tyrosine kinase inhibitor failure in patients with chronic myeloid leukemia. J Leuk 2015;3(1):170.</mixed-citation><mixed-citation xml:lang="ru">Kropf P., Barnes G., Tang B.. et al. Burden of tyrosine kinase inhibitor failure in patients with chronic myeloid leukemia. J Leuk 2015;3(1):170.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Hirji I., Gupta S., Goren A. et al. Chronic myeloid leukemia (CML): association of treatment satisfaction, negative medication experience and treatment restrictions with health outcomes. From the patients’ perspective. Health and quality of life outcomes. 2013;11:167.</mixed-citation><mixed-citation xml:lang="ru">Hirji I., Gupta S., Goren A. et al. Chronic myeloid leukemia (CML): association of treatment satisfaction, negative medication experience and treatment restrictions with health outcomes. From the patients’ perspective. Health and quality of life outcomes. 2013;11:167.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Абдулкадыров К.М., Абдуллаев А.О., Авдеева Л.Б. и др. Федеральные клинические рекомендации по диагностике и терапии хронического миелолейкоза. Вестник гематологии 2013;IX;(3):4–39. [Abdulkadyrov K.M., Abdullaev A.O., Avdeeva L.B. et al. Fedеral clinical guidelines for chronic myelogenous leukemia diagnosis and treatment. Vestnik gematologii = The Bulletin of Hematology 2013;IX;(3):4–39. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Абдулкадыров К.М., Абдуллаев А.О., Авдеева Л.Б. и др. Федеральные клинические рекомендации по диагностике и терапии хронического миелолейкоза. Вестник гематологии 2013;IX;(3):4–39. [Abdulkadyrov K.M., Abdullaev A.O., Avdeeva L.B. et al. Fedеral clinical guidelines for chronic myelogenous leukemia diagnosis and treatment. Vestnik gematologii = The Bulletin of Hematology 2013;IX;(3):4–39. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Carlson M.E., Pompei P., Ales K.L. et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373–83.</mixed-citation><mixed-citation xml:lang="ru">Carlson M.E., Pompei P., Ales K.L. et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373–83.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Breccia M., Latagliata R., Stagno F. et al. Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib. Haematologica 2011;96(10):1457–61.</mixed-citation><mixed-citation xml:lang="ru">Breccia M., Latagliata R., Stagno F. et al. Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib. Haematologica 2011;96(10):1457–61.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Hays R.D., Sherbourne C.D., Mazel R.M. User’s Manual for Medical Outcomes Study (MOS) Core measures of health-related quality of life. RAND Corporation, MR-162-RC (available at www.rand.org).</mixed-citation><mixed-citation xml:lang="ru">Hays R.D., Sherbourne C.D., Mazel R.M. User’s Manual for Medical Outcomes Study (MOS) Core measures of health-related quality of life. RAND Corporation, MR-162-RC (available at www.rand.org).</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Nikitina T.P., Fedorenko D.A., Kurbatova K.A. et al.Comprehensive symptom profile in patients with chronic myeloid leukemia: practicability and sensitivity of the new symptom assessment tool CSP Leuk-CML. Haematologica 2014;(Suppl):B1674.</mixed-citation><mixed-citation xml:lang="ru">Nikitina T.P., Fedorenko D.A., Kurbatova K.A. et al.Comprehensive symptom profile in patients with chronic myeloid leukemia: practicability and sensitivity of the new symptom assessment tool CSP Leuk-CML. Haematologica 2014;(Suppl):B1674.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">39. Hochhaus A., Hagop M., Kantarjian H. et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007;109(6): 2303–9.</mixed-citation><mixed-citation xml:lang="ru">Hochhaus A., Hagop M., Kantarjian H. et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007;109(6): 2303–9.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">40. Rosti G., Castagnetti F., Gugliotta G. et al. Dasatinib and nilotinib in imatinib resistant</mixed-citation><mixed-citation xml:lang="ru">Rosti G., Castagnetti F., Gugliotta G. et al. Dasatinib and nilotinib in imatinib resistant</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><mixed-citation>Philadelphia-positive chronic myelogenous leukemia: a “head-to-head” comparison. Leuk Lymphoma 2010;51:583–91.</mixed-citation></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">41. Khoury J., Guilhot F., Hughes T. et al. Dasatinib treatment for Philadelphia chromosome-positive leukemias practical considerations. Cancer 2009;115:1381–4.</mixed-citation><mixed-citation xml:lang="ru">Khoury J., Guilhot F., Hughes T. et al. Dasatinib treatment for Philadelphia chromosome-positive leukemias practical considerations. Cancer 2009;115:1381–4.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">42. Quintas-Cardama A., Pires De Souza Santos F., Kantarjian H. et al. Dynamics and management of cytopenias associated withdasatinib therapy in patients with chronic myeloid leukemia in chronic phase after imatinib failure cancer. Cancer 2009;115(7):3935–43.</mixed-citation><mixed-citation xml:lang="ru">Quintas-Cardama A., Pires De Souza Santos F., Kantarjian H. et al. Dynamics and management of cytopenias associated withdasatinib therapy in patients with chronic myeloid leukemia in chronic phase after imatinib failure cancer. Cancer 2009;115(7):3935–43.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">43. Jabbour E., Deininger M., Hochhaus A. Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia 2011;25:201–10.</mixed-citation><mixed-citation xml:lang="ru">Jabbour E., Deininger M., Hochhaus A. Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia 2011;25:201–10.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">44. Krauth M., Herndlhofer S., Schmook M. et al. Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily. Haematologica 2011;96(1):163–6.</mixed-citation><mixed-citation xml:lang="ru">Krauth M., Herndlhofer S., Schmook M. et al. Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily. Haematologica 2011;96(1):163–6.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">45. Quintas-Cardama A., Kantarjian H., O’Brien S. et al. Effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol 2007;25:136–40.</mixed-citation><mixed-citation xml:lang="ru">Quintas-Cardama A., Kantarjian H., O’Brien S. et al. Effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol 2007;25:136–40.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">46. Masiello D., Gorospe G.S., Yang A.S. The occurrence and management of fluid retention associated with TKI therapy in CML, with a focus on dasatinib. J Hematol Oncol 2009;12(2):46.</mixed-citation><mixed-citation xml:lang="ru">Masiello D., Gorospe G.S., Yang A.S. The occurrence and management of fluid retention associated with TKI therapy in CML, with a focus on dasatinib. J Hematol Oncol 2009;12(2):46.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">47. Nagata Y., Ohashi K., Fukuda S. et al. Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion. Int J Hematol 2010;91:799–807.</mixed-citation><mixed-citation xml:lang="ru">Nagata Y., Ohashi K., Fukuda S. et al. Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion. Int J Hematol 2010;91:799–807.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
