OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press1510.17650/1818-8346-2013-8-4-24-31HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯNeuromuscular disorders in acute leukemia and lymphoma treatmentНервно-мышечные расстройства при терапии острых лейкозов и лимфом (обзор литературы)PolitovaE. A.ПолитоваЕ. А.
Russian Federation

Department of Neurology, Neurosurgery and Medical Genetics

кафедра неврологии, нейрохирургии и медицинской генетики

nervine-polite@mail.ruZavadenkoN. N.ЗаваденкоН. Н.
Russian Federation

Department of Neurology, Neurosurgery and Medical Genetics

кафедра неврологии, нейрохирургии и медицинской генетики

РумянцевА. Г.
Russian Federation
Dmitriy Rogachev Federal Research Centеr of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России ГБОУ ВПО «Российский национальный исследовательский университет им. Н. И. Пирогова» Минздрава РоссииPirogov Russian National Research Medical University, Ministry of Health of RussiaГБОУ ВПО «Российский национальный исследовательский университет им. Н. И. Пирогова» Минздрава РоссииDmitriy Rogachev Federal Research Centеr of Pediatric Hematology, Oncology and Immunology, Ministry of Health of RussiaФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава Россииru2111201320138424312107201421072014Received:21072014Accepted:21072014Published:211120132013https://oncohematology.abvpress.ru/ongm/article/view/15

Different mechanisms of neuromuscular complications, their clinical presentation, methods of diagnosis, prognosis and treatment options arepresented. The material is presented according to the level of nervous system damage, with inclusion of different clinical entities. Authors revieweda wide range of disease – disease of the spinal cord, peripheral nerves and plexus, neuromuscular junction and muscle – as a result of chemotherapy and radiation therapy. Systemic effects of drugs on peripheral nervous system, various departments of which can be simultaneously involved in the pathological process, were also highlighted.

В статье представлены различные патогенетические механизмы развития нервно-мышечных осложнений, варианты их клинической картины, методы диагностики, прогноза и принципы терапии. Обзор структурирован по уровням поражения нервной системы, с включением различных нозологических форм. Подробно рассмотрены заболевания спинного мозга, периферических нервов и сплетений, нервно-мышечного синапса и мышц как результат воздействия химиопрепаратов и лучевой терапии. Подчеркнута системность действия компонентов программной терапии на периферическую нервную систему, различные отделы которой могут быть одновременно вовлечены в патологический процесс.

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