OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press14710.17650/1818-8346-2015-10-2-63-68BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕComparison of harvesting methods and clinical application of apheresis platelet concentrates with additive solutionСравнительная характеристика методов заготовки и клинического применения аферезных концентратов тромбоцитов с использованием добавочного раствораKarpovaO. V.КарповаО. В.
Russian Federation
ovk_67@mail.ruObraztsovI. V.ОбразцовИ. В.
Russian Federation
TrakhtmanP. E.ТрахтманП. Е.
Russian Federation
IgnatovaA. A.ИгнатоваА. А.
Russian Federation
PanteleevM. A.ПантелеевМ. А.
Russian Federation
RumyantsevS. A.РумянцевС. А.
Russian Federation
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России1 Samory Mashela St., Moscow, 117198, RussiaРоссия, 117198, Москва, ул. Саморы Машела, 11 Samory Mashela St., Moscow, 117198, Russia Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of SciencesРоссия, 117198, Москва, ул. Саморы Машела, 1 ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН38A, Bldg. 1 Leninskiy Prosp., Moscow, 119991, Russia M.V. Lomonosov Moscow State UniversityРоссия, 119991, Москва, Ленинский просп., 38А, корп. 1 ФГБОУ ВПО «Московский государственный университет им. М. В. Ломоносова»1 Leninskie Gory St., Moscow, 119234, RussiaРоссия, 119234, Москва, ул. Ленинские горы, 11 Samory Mashela St., Moscow, 117198, Russia N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaРоссия, 117198, Москва, ул. Саморы Машела, 1 ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России1 Ostrovityanova St., Moscow, 117997, Russia Moscow Institute of Physics and Technology (State University)Россия, 117997, Москва, ул. Островитянова, 1 ФГАОУ ВПО «Московский физико-технический институт (государственный университет)»9 Institutskiy per., Dolgoprudnyy, Moscow Region, Russia, 141700Россия, 141700, Московская область, Долгопрудный, Институтский пер., 90406201510263680406201504062015https://oncohematology.abvpress.ru/ongm/article/view/147

Platelet concentrates (PC) are used worldwide in the fields of oncology, oncohaematology and bone marrow transplantation. One of the main tasks of clinical transfusiology is the development and improvement of technologies aimed to increase quality and safety of PC. In particular, such technologies are represented by using of platelet additive solutions (PAS). The main advantages of this approach are: a reduction of immune and non-immune transfusion reactions risk, an improvement of pathogen inactivation quality and enhancing a clinical effect of PC transfusions after storage. Numerous different PAS and methodologies of their application are suggested to date. In this review we have described and classified recent data on different PAS and the benefits of their clinical application.

Использование концентратов тромбоцитов (КТ) нашло повсеместное применение в области онкологии, онкогематологии и трансплантации костного мозга. Одной из основных задач клинической трансфузиологии является разработка и совершенствование технологий, направленных на улучшение качества и безопасности КТ. К таким технологиям относится, в частности, применение добавочных растворов (ДР). Существенными достоинствами этого подхода являются: снижение риска иммунных и неиммунных трансфузионных реакций, повышение качества инактивации патогенов, а также улучшение клинического эффекта трансфузий КТ после хранения. На сегодняшний день предложено большое количество различных ДР и методик их использования. В настоящем обзоре систематизированы современные данные о возможностях применения различных ДР и преимуществах их использования в клинической практике.

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