OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press13010.17650/1818-8346-2014-9-4-37-45BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕComparison of platelets characteristics according to various processing methodsСравнение морфофункциональных свойств тромбоцитов в зависимости от различных способов процессингаKarpovaO. V.КарповаО. В.
Russian Federation
ObraztsovI. V.ОбразцовИ. В.
Russian Federation
TrakhtmanP. E.ТрахтманП. Е.
Russian Federation
Ignatova1A. A.ИгнатоваА. А.
Russian Federation
PanteleevM. A.ПантелеевМ. А.
Russian Federation
RumyantsevS. A.РумянцевС. А.
Russian Federation
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, MoscowФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России, Москва1, Samory Mashela st., Moscow, Russia, 117198117198, Россия, Москва, ул. Саморы Машела, 11, Samory Mashela st., Moscow, Russia, 117198 Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow117198, Россия, Москва, ул. Саморы Машела, 1 ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН, Москва4, Kosygina st., Moscow, Russia, 119991 M.V. Lomonosov Moscow State University119991, Россия, Москва, ул. Косыгина, 4 ГБОУ ВПО «Московский государственный университет им. М.В. Ломоносова»1, Leninskie gory, Moscow, Russia, 119991119991, Россия, Москва, Ленинские горы, 11, Samory Mashela st., Moscow, Russia, 117198 N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow117198, Россия, Москва, ул. Саморы Машела, 1 ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва1, Ostrovityanova st., Moscow, Russia, 117997 Moscow Institute of Physics and Technology State University117997, Россия, Москва, ул. Островитянова, 1 ФГАОУ ВПО «Московский физико-технический институт (государственный университет)», Долгопрудный9, Institutskiy per., Dolgoprudnyi, Moscow Oblast, Russia, 141700141700, Россия, Московская область, Долгопрудный, Институтский переулок, 93012201494374530012015300120152014https://oncohematology.abvpress.ru/ongm/article/view/130

To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphological and functional characteristics of platelets and, as a consequence, the clinical efficacy of transfusions is controversial. In this paper we analyzed the impact of the platelet storage solution and different methods of pathogen inactivation (X-rays, UV-irradiation after photosensitization with riboflavin) on morphological and functional parameters of platelets. Our findings allow optimizing the technology of preparation and processing of PC to achieve greater effectiveness of transfusion therapy.

На сегодняшний день предложены различные технологии заготовки и обработки концентратов тромбоцитов (КТ), направленные на достижение максимальной эффективности трансфузий и минимизацию рисков посттрансфузионных реакций. Однако данные по влиянию различных подходов к процессингу КТ на морфофункциональные характеристики тромбоцитов и, как следствие, на клиническую эффективность трансфузий неоднозначны. В работе проанализировано влияние применения добавочного раствора при заготовке и использования методов инактивации патогенов (рентгеновское облучение, облучение ультрафиолетом после фотосенсибилизации рибофлавином) на морфологические и функциональные параметры тромбоцитов в КТ. Полученные данные позволяют оптимизировать технологию заготовки и обработки КТ для достижения большей эффективности трансфузионной терапии.

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