OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press1310.17650/1818-8346-2013-8-4-13-17HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯFrequency of red cell, leukocytic and platelet alloantibodies in patients with hematological diseasesЧастота выявления антиэритроцитарных, антилейкоцитарных, антитромбоцитарных аллоантител у больных гематологическими заболеваниямиMineevaN. V.МинееваН. В.
Russian Federation
GavrovskayaS. V.ГавровскаяС. В.
Russian Federation
mousemoon@mail.ruKrobinetsI. I.КробинецИ. И.
Russian Federation
PashkovaI. A.ПашковаИ. А.
Russian Federation
BodrovaN. N.БодроваН. Н.
Russian Federation
SysoevaE. A.СысоеваЕ. А.
Russian Federation
Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological AgencyФГБУ РосНИИГТ ФМБА России2111201384131721072014210720142013https://oncohematology.abvpress.ru/ongm/article/view/13

History of multiple transfusions in patients with hematological diseases increases the likelihood of immunization to donor blood cells antigensand immunological complications development. Incidence of alloantibodies development in this patients was assessed in this work. Alloantibodies detection was performed in patients with aplastic anemia, acute leukemia, chronic lymphocytic leukemia, and autoimmune thrombocytopenia. 9696 patients were included in this study. Frequency of alloantibodies to red cell antigens was 3.8 %, with 0.9 % of the antibody belong to the immunoglobulin G, and 2.9 % of the cases – to immunoglobulin M. Most of the IgG antibodies had following specificity:monospecific anti-D antibody (21 cases), anti-DC and anti-DE antibodies (4 cases), anti-C (8 cases), anti-E (15), anti-c (13), and anti-K (11). Anti-e (1), anti-Fya (2), anti-Lea (4), anti-S (2), anti-s (2), anti-Jka (2) antibodies were less common. Granulocytes antibodies were found in 66.7 % of 384 patients, with results dependent on the detection method used. The presence of antiplatelet alloantibodies studied in 285 serum samples, of which antibodies were detected in 99 patients (34.7 %). Specificity of platelet antibodies was determined in three serum samples only: anti-2b, anti-1a, anti-1b. In other patients, probably present antibodies to several antigens simultaneously, and to identify them was not possible.

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