OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press12410.17650/1818-8346-2014-9-3-63-66EDUCATIONAL LECTURES, REVIEWSОБРАЗОВАТЕЛЬНЫЕ ЛЕКЦИИ, ОБЗОРЫProgrammed cell death of platelets during their overactivationПрограммируемая клеточная смерть тромбоцитов при их сверхактивацииArtemenkoE. O.АртеменкоЕ. О.
Russian Federation
SveshnikovaA. N.СвешниковаА. Н.
Russian Federation
PanteleevM. A.ПантелеевМ. А.
Russian Federation
mapanteleev@yandex.ruCentre for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, MoscowФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН, Москва ФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России, МоскваCentre for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow M.V. Lomonosov Moscow State UniversityФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН, Москва ФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева Минздрава России, Москва ГБОУ ВПО «Московский государственный университет им. М. В. Ломоносова»3010201493636630012015300120152014https://oncohematology.abvpress.ru/ongm/article/view/124

Programmed cell death – it is a cell death by a strictly defined mechanism with possible impact on him and, due to this, the death control, including using of pharmacological agents. Currently known many different types of cell death, but only two basic types of cell death are adequately characterized: apoptosis and programmed necrosis. Platelets are one of the key components of the blood clotting process. A group of platelets, exposing phosphatidylserine (PS), with the programmed cell death characteristics appears at their critical agonist-induced activation. This overactivation of platelets accompanied by subsequent cell death is not completely characterized cellular processes. We view the platelets overactivation in comparison with the main known types of cell death because the platelets group exposing PS is important for bloodcoagulation processes, accelerating by several orders the plasma coagulation, and important for the thrombus formation.

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