OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press12110.17650/1818-8346-2014-9-3-32-40HEMATOPOIETIC STEM CELL TRANSPLANTATIONТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК У ПАЦИЕНТОВ С ГЕМОБЛАСТОЗАМИThe optimal time for hematopoietic stem cell translantation for Hodgkin's lymphoma. International guidelines and real practic in Russia and former USSSR countries (Part II)Оптимальные сроки проведения аутологичной трансплантации клеток предшественников гемопоэза при неблагоприятном течении лимфомы Ходжкина. Зарубежные рекомендации и отечественная практика (часть II)ZhukovN. V.ЖуковН. В.
Russian Federation
UssA. L.УссА. Л.
Russian Federation
MilanovichN. F.МилановичН. Ф.
Russian Federation
PtushkinV. V.ПтушкинВ. В.
Russian Federation
AfanasievB. V.АфанасьевБ. В.
Russian Federation
MikhaylovaN. B.МихайловаН. Б.
Russian Federation
LarionovaV. B.ЛарионоваВ. Б.
Russian Federation
DeminaYe. A.ДеминаЕ. А.
Russian Federation
TyurinaN. G.ТюринаН. Г.
Russian Federation
VernyukM. A.ВернюкМ. А.
Russian Federation
KaramaneshtYe. Ye.КараманештЕ. Е.
Russian Federation
RumyantsevA. G.РумянцевА. Г.
Russian Federation
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow N.I..Pirogov Russian National Research Medical University, Ministry of Health of Russia, MoscowФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России, МоскваRepublic Center of Hematology and Bone Marrow Transplantation, Minsk, BelarusРеспубликанский центр гематологии и пересадки костного мозга, Минск, Республика БеларусьRaisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaНИИ детской онкологии, гематологии и трансплантологии им. Р. М. Горбачевой ГБОУ ВПО Первый СПбГМУ им. акад. И. П. Павлова Минздрава РоссииN.N. Blokhin Russian Cancer Research Center, MoscowФГБНУ «РОНЦ им. Н. Н. Блохина», МоскваP.A. Gertsen Moscow Research Oncology Institute, Ministry of Health of RussiaФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава РоссииKiev Center of Bone Marrow Transplantation, UkraineКиевский центр трансплантации костного мозга, Украина3010201493324030012015300120152014https://oncohematology.abvpress.ru/ongm/article/view/121

The influence of previous antitumor therapy the efficacy and tolerability of high-dose chemotherapy with autologous hematopoietic progenitor cells transplantation (HCST) in 369 patients with Hodgkin, s lymphoma in the clinics of Russia and CIS countries was analyzed. Longterm treatment results of patients who have received 1 or 2 therapy lines before deciding about HCST were comparable (5‑year overall survival (OS) – 67 ± 3.8 % and 71 ± 5.0 %; freedom from treatment failure survival (FFTF) – 52.6 ± 3.9 % and 61 ± 5.0 %, respectively). The worst results (p < 0.05) are in patients who have received > 2 lines of therapy prior HSCT (5‑year OS – 46 ± 9.7 %, FFTF – 38.4 ± 9.0 %). The negative impact of previous treatment on the efficiency of hematopoietic material collection and hematopoiesis reconstitution as well observed in patients who received > 2 lines of therapy. Therefore, if the delay of HSCT in patients who achieved remission on secondline therapy was caused by organizational problems, for optimum results is necessary to conduct HSCT not later than second relapse while maintaining tumor chemosensitivity (third disease remission). However, when remission is not achieved after second-line therapy, is necessary to change the treatment regimen and performing HSCT only at confirmation of tumor chemosensitivity, because regardless of prior therapy line number, this approach leads to better results than earlier performing HSCT without remission.

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