OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press12010.17650/1818-8346-2014-9-3-25-31HEMATOPOIETIC STEM CELL TRANSPLANTATIONТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК У ПАЦИЕНТОВ С ГЕМОБЛАСТОЗАМИAnalysis of the results of allogeneic hematopoietic stem cell transplantation depending on HLA matching of the unrelated donor / recipient pairАнализ результатов аллогенной трансплантации гемопоэтических стволовых клеток в зависимости от степени HLA-подбора пациента и неродственного донораKuzmichYe. V.КузьмичЕ. В.
Russian Federation
yelenakuzmich@gmail.comAlyanskiyA. I.АлянскийА. Л.
Russian Federation
IvanovaN. Ye.ИвановаН. Е.
Russian Federation
VitrischakA. A.ВитрищакА. А.
Russian Federation
VladovskayaM. D.ВладовскаяМ. Д.
Russian Federation
MorozovaYe. V.МорозоваЕ. В.
Russian Federation
BondarenkoS. N.БондаренкоС. Н.
Russian Federation
SemenovaYe. V.СеменоваЕ. В.
Russian Federation
ZubarovskayaL. S.ЗубаровскаяЛ. С.
Russian Federation
AfanasyevB. V.АфанасьевБ. В.
Russian Federation
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaНИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой ГБОУ ВПО Первый СПбГМУ им. акад. И.П. Павлова Минздрава России3010201493253130012015300120152014https://oncohematology.abvpress.ru/ongm/article/view/120

HLA matching of the donor / recipient pair is a major factor associated with the outcome of allogeneic stem cell transplantation. In the presentstudy we analyzed the risk of severe acute graft-versus-host disease, graft failure, 2.year overall survival of the patients after allogeneic stem cell transplantation depending on HLA matching of the unrelated donor / recipient pair.

Степень совместимости пациента и потенциального донора по HLA-системе является важным фактором, ассоциированным с клиническим исходом аллогенной трансплантации гемопоэтических стволовых клеток (алло-ТГСК). В работе представлены результаты анализа частоты первичного неприживления трансплантата, риска развития острой реакции «трансплантат против хозяина» III–IV степени, общей 2‑летней выживаемости пациентов после алло-ТГСК в зависимости от степени HLA-подбора пациента и неродственного донора.

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