OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press11610.17650/1818-8346-2014-9-2-58-64BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕGenetic restriction of humoral immune responseГенетическая рестрикция гуморального иммунного ответаGolovkinaL. L.ГоловкинаЛ. Л.
Russian Federation
largol@mail.ruHematology Research Center, Ministry of Health of Russia, MoscowФГБУ ГНЦ Минздрава России, Москва170920149258641709201417092014https://oncohematology.abvpress.ru/ongm/article/view/116

The review provides information about immune response initiation against foreign agents. Significance of separate molecules of major histocompatibility complex in antibodies formation after blood transfusion, during pregnancy, after organ transplantation due to incompatibility of the antigenic structures of donor and recipient, mother and child was shown. Detailed description of platelet antigens protein structure significance in immunocompetent cells recognition of them is provided.

В обзоре приводятся сведения о путях инициации иммунного ответа при попадании в организм человека чужеродных агентов. Показано значение отдельных молекул главного комплекса гистосовместимости в запуске антителообразования после трансфузий компонентов крови, в процессе беременности, после трансплантации органов вследствие несовместимости антигенных структур донора и реципиента, матери и ребенка. Подробно описано значение строения белковых молекул антигенов тромбоцитов в распознавании их иммунокомпетентными клетками.

immune response restrictiongenes and antigens of major histocompatibility complex HLA (Human Leukocyte Antigens)platelet- specific genes of HPA system (Human Platelet Antigens)alloimmunizationtransfusiologyneonatal alloimmune thrombocytopenic puрестрикция иммунного ответагены и антигены главного комплекса гистосовместимости системы HLAтромбоцитспецифические гены системы НРАаллоиммунизациятрансфузиологиянеонатальная аллоиммунная тромбоцитопеническая пурпураорганная трансплантация1. Nyholm S. V., Passeque E., Ludington W. B. et al. A candidate allorecognition receptor from a primitiveNyholm S. V., Passeque E., Ludington W. B. et al. A candidate allorecognition receptor from a primitivechordate. Immunity 2006;25:163–73.2. Rinkevich B. Primitive immune systems: are you ways my ways? Immunology Rev 2004;198:25–35.Rinkevich B. Primitive immune systems: are you ways my ways? Immunology Rev 2004;198:25–35.3. Zinkernagel R. M., Doherty P. C. 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