<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">108</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2011-6-1-76-84</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>LECTURES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЛЕКЦИИ ДЛЯ ВРАЧЕЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Mechanisms of signal transduction</article-title><trans-title-group xml:lang="ru"><trans-title>Механизмы реализации сигнальной трансдукции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Domninskiy</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Домнинский</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>D7777777@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Research Center of Pediatric Hematology, Oncology and Immunology</institution></aff><aff><institution xml:lang="ru">ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии&#13;
Минздравсоцразвития России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-02-24" publication-format="electronic"><day>24</day><month>02</month><year>2011</year></pub-date><volume>6</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>76</fpage><lpage>84</lpage><history><date date-type="received" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2011</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/108">https://oncohematology.abvpress.ru/ongm/article/view/108</self-uri><abstract xml:lang="en"><p>.</p></abstract><trans-abstract xml:lang="ru"><p>.</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Владимирская Е.Б. Механизмы кроветворения и лейкемогенеза (цикл лекций). М.: Династия, 2007.</mixed-citation><mixed-citation xml:lang="ru">Владимирская Е.Б. Механизмы кроветворения и лейкемогенеза (цикл лекций). М.: Династия, 2007.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Копнин Б.П. Мишени действия онкогенов и опухолевых супрессоров: ключ к пониманию базовых механизмов канцерогенеза. Биохимия 2000;65:5–33.</mixed-citation><mixed-citation xml:lang="ru">Копнин Б.П. Мишени действия онкогенов и опухолевых супрессоров: ключ к пониманию базовых механизмов канцерогенеза. Биохимия 2000;65:5–33.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Копнин Б.П. Механизмы действия онкогенов и опухолевых супрессоров, 2002 (есть несколько электронных версий этого обзора, см., например: http://longevitylibrary. narod.ru/1/1.1/1.1.21.htm).</mixed-citation><mixed-citation xml:lang="ru">Копнин Б.П. Механизмы действия онкогенов и опухолевых супрессоров, 2002 (есть несколько электронных версий этого обзора, см., например: http://longevitylibrary. narod.ru/1/1.1/1.1.21.htm).</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Scott J., Pawson T. Cell signaling in space and time: where proteins come together and when they’re apart. Science 2009;326:1220–4.</mixed-citation><mixed-citation xml:lang="ru">Scott J., Pawson T. Cell signaling in space and time: where proteins come together and when they’re apart. Science 2009;326:1220–4.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Lodish H., Berk A., Matsudaira P. et al. Molecular cell biology. UK, Freeman &amp; Co, 5 ed., 2004.</mixed-citation><mixed-citation xml:lang="ru">Lodish H., Berk A., Matsudaira P. et al. Molecular cell biology. UK, Freeman &amp; Co, 5 ed., 2004.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Ferrando A. The role of Notch1 signaling in T-ALL. Hematology 2009:353–61.</mixed-citation><mixed-citation xml:lang="ru">Ferrando A. The role of Notch1 signaling in T-ALL. Hematology 2009:353–61.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Citri A., Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 2006;7:505–16.</mixed-citation><mixed-citation xml:lang="ru">Citri A., Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 2006;7:505–16.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Taniguchi C., Emanuelli B., Kahn R. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006;7:85–96.</mixed-citation><mixed-citation xml:lang="ru">Taniguchi C., Emanuelli B., Kahn R. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006;7:85–96.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Peisajovich S., Garbarino J., Wie P., Lim W. Rapid diversification of cell signaling phenotypes by modular domain recombination. Science 2010;328:368–72.</mixed-citation><mixed-citation xml:lang="ru">Peisajovich S., Garbarino J., Wie P., Lim W. Rapid diversification of cell signaling phenotypes by modular domain recombination. Science 2010;328:368–72.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Pryciak P. Designing new cellular signaling pathways. Chem Biol 2009;16:249–54.</mixed-citation><mixed-citation xml:lang="ru">Pryciak P. Designing new cellular signaling pathways. Chem Biol 2009;16:249–54.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Lim W. Designing customized cell signalling circuits. Nat Rev Mol Cell Biol 2010;11:293–403.</mixed-citation><mixed-citation xml:lang="ru">Lim W. Designing customized cell signalling circuits. Nat Rev Mol Cell Biol 2010;11:293–403.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001;411:355–65.</mixed-citation><mixed-citation xml:lang="ru">Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001;411:355–65.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Lemmon M., Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010;141:1117–34.</mixed-citation><mixed-citation xml:lang="ru">Lemmon M., Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010;141:1117–34.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Hubbard S. Juxtamembrane autoinhibition in receptor tyrosine kinases. Nat Rev Mol Cell Biol 2004;5:464–71.</mixed-citation><mixed-citation xml:lang="ru">Hubbard S. Juxtamembrane autoinhibition in receptor tyrosine kinases. Nat Rev Mol Cell Biol 2004;5:464–71.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Swanson C., Paniagua R., Lindstrom T., Robinson W. Tyrosine kinases as targets for the treatment of rheumatoid arthritis. Nat Rev Rheumatology 2009;5:317–24.</mixed-citation><mixed-citation xml:lang="ru">Swanson C., Paniagua R., Lindstrom T., Robinson W. Tyrosine kinases as targets for the treatment of rheumatoid arthritis. Nat Rev Rheumatology 2009;5:317–24.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Le Roy C., Wrana J. Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol 2005;6:112–26.</mixed-citation><mixed-citation xml:lang="ru">Le Roy C., Wrana J. Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol 2005;6:112–26.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Sorkin A., von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol 2009;10:609–22.</mixed-citation><mixed-citation xml:lang="ru">Sorkin A., von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol 2009;10:609–22.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Wang Y-N., Yamaguchi H., Hsu J-M., Hung M-C. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene 2010;29:3997–4006.</mixed-citation><mixed-citation xml:lang="ru">Wang Y-N., Yamaguchi H., Hsu J-M., Hung M-C. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene 2010;29:3997–4006.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Rozengurt E. Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol 2007;213:589–602.</mixed-citation><mixed-citation xml:lang="ru">Rozengurt E. Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol 2007;213:589–602.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Hancock J. Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol 2003;4:373–85.</mixed-citation><mixed-citation xml:lang="ru">Hancock J. Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol 2003;4:373–85.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Schubbert S., Shannon K., Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007;7:295–308.</mixed-citation><mixed-citation xml:lang="ru">Schubbert S., Shannon K., Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007;7:295–308.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Mardilovich K., Pankratz S., Shaw L. Expression and function of the insulin receptor substrate proteins in cancer. Cell Comm Signaling 2009;7:14–28.</mixed-citation><mixed-citation xml:lang="ru">Mardilovich K., Pankratz S., Shaw L. Expression and function of the insulin receptor substrate proteins in cancer. Cell Comm Signaling 2009;7:14–28.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Bhaskar P., Hay N. The two TORCs and Akt. Develop Cell 2007;12:487–502.</mixed-citation><mixed-citation xml:lang="ru">Bhaskar P., Hay N. The two TORCs and Akt. Develop Cell 2007;12:487–502.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Simons K., Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31–9.</mixed-citation><mixed-citation xml:lang="ru">Simons K., Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31–9.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Wymann M., Schneiter R. Lipid signalling in disease. Nat Rev Mol Cell Biol 2008; 9:162–76.</mixed-citation><mixed-citation xml:lang="ru">Wymann M., Schneiter R. Lipid signalling in disease. Nat Rev Mol Cell Biol 2008; 9:162–76.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Groves J., Kuriyan J. Molecular mechanisms in signal transduction at the membrane. Nat Structur Mol Biol 2010;17:659–65.</mixed-citation><mixed-citation xml:lang="ru">Groves J., Kuriyan J. Molecular mechanisms in signal transduction at the membrane. Nat Structur Mol Biol 2010;17:659–65.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Kurosaki T. Regulation of B-cell signal ransduction by adaptor proteins. Nat Rev Immunol 2002;2:354–63.</mixed-citation><mixed-citation xml:lang="ru">Kurosaki T. Regulation of B-cell signal ransduction by adaptor proteins. Nat Rev Immunol 2002;2:354–63.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Seet B., Dikic I., Zhou M., Pawson T. Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol 2006;7:473–83 (см. также постер этих авторов — http://www.nature.com/nrm/posters/modifications/nrm0706-poster-web.pdf).</mixed-citation><mixed-citation xml:lang="ru">Seet B., Dikic I., Zhou M., Pawson T. Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol 2006;7:473–83 (см. также постер этих авторов — http://www.nature.com/nrm/posters/modifications/nrm0706-poster-web.pdf).</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Buday L., Tompa P. Functional classification of scaffold proteins and related molecules. FEBS J 2010;277:4348–55.</mixed-citation><mixed-citation xml:lang="ru">Buday L., Tompa P. Functional classification of scaffold proteins and related molecules. FEBS J 2010;277:4348–55.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Welchman R., Gordon C., Mayer J. Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol 2005;6:599–609.</mixed-citation><mixed-citation xml:lang="ru">Welchman R., Gordon C., Mayer J. Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol 2005;6:599–609.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Hoeller D., Hecker C-M., Dikic I. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 2006;6:776–88.</mixed-citation><mixed-citation xml:lang="ru">Hoeller D., Hecker C-M., Dikic I. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat Rev Cancer 2006;6:776–88.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Chen Z., Sun L. Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 2009;33:275–86.</mixed-citation><mixed-citation xml:lang="ru">Chen Z., Sun L. Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 2009;33:275–86.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
