OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press103310.17650/1818-8346-2025-20-2-87-103BASIC RESEARCHФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В ПРАКТИЧЕСКОЙ МЕДИЦИНЕ НА СОВРЕМЕННОМ ЭТАПЕThe significance of miR-142 in tumor progression of diffuse large B-cell lymphomaЗначение miR-142 в опухолевой прогрессии диффузной В-клеточной крупноклеточной лимфомыhttps://orcid.org/0000-0001-7542-7285VoropaevaE. N.ВоропаеваЕ. Н.
Russian Federation

52 Krasny Prospekt, Novosibirsk 630091 

175/1 B. Bogatkova St., Novosibirsk 630089 

Елена Николаевна Воропаева

630091 Новосибирск, Красный пр-кт, 52

630089 Новосибирск, ул. Б. Богаткова, 175/1 

vena.81@mail.ruhttps://orcid.org/0000-0002-6110-4351SereginaO. B.СерегинаО. Б.
Russian Federation

2 Krasny Prospekt, Novosibirsk 630091

630091 Новосибирск, Красный пр-кт, 52

https://orcid.org/0000-0002-5429-4011VoytkoM. S.ВойткоМ. С.
Russian Federation

2 Krasny Prospekt, Novosibirsk 630091

630091 Новосибирск, Красный пр-кт, 52

https://orcid.org/0000-0002-2708-1133BabaevaT. N.БабаеваТ. Н.
Russian Federation

2 Krasny Prospekt, Novosibirsk 630091

630091 Новосибирск, Красный пр-кт, 52

https://orcid.org/0000-0001-6938-3802SkvortsovaN. V.СкворцоваН. В.
Russian Federation

2 Krasny Prospekt, Novosibirsk 630091

630091 Новосибирск, Красный пр-кт, 52

https://orcid.org/0000-0002-7165-4496MaksimovV. N.МаксимовВ. Н.
Russian Federation

2 Krasny Prospekt, Novosibirsk 630091

175/1 B. Bogatkova St., Novosibirsk 630089 

630091 Новосибирск, Красный пр-кт, 52

630089 Новосибирск, ул. Б. Богаткова, 175/1 

https://orcid.org/0000-0002-1261-5470PospelovaT. I.ПоспеловаТ. И.
Russian Federation

52 Krasny Prospekt, Novosibirsk 630091

630091 Новосибирск, Красный пр-кт, 52

Novosibirsk State Medical UniversityФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииThe Institute of Internal and Preventive Medicine – branch of the Federal Research Center, Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of SciencesНИИ терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»22052025202871032005202520052025https://oncohematology.abvpress.ru/ongm/article/view/1033

In recent years, microRNAs have attracted the attention of researchers as potential markers for diagnosis, classification, prognosis of tumor progression and sensitivity to treatment, as well as their use as targets for therapy. The purpose of the review is to summarize data on the miR-142 role in the tumor progression of one of the most common lymphoproliferative diseases – diffuse large B-cell lymphoma.MicroRNA miR-142 has a broad spectrum of tumor-suppressor functions by targeting a number of important protooncogenes, the loss of control over which contributes to enhanced proliferation, blocking apoptosis, activating B-lymphocyte survival signaling pathways, metabolic reprogramming, creating an immunosuppressive microenvironment and tumor evasion of immune surveillance, as well as dissemination of malignant cells.Information on the nomenclature and mechanisms of miR-142 formation, the participation of miR-142 in hematopoiesis are provided, the pathogenetic role and relationship between the miR-142 expression profile and diffuse large B-cell lymphoma are analyzed, and miR-142 molecular genetic abnormalities in this disease are discussed.

В последние годы микроРНК привлекли внимание исследователей в области онкогематологии как потенциальные маркеры для диагностики, классификации, прогнозирования особенностей течения и чувствительности к лечению опухолей, а также их использования в качестве мишеней для таргетной терапии.Цель обзора – обобщение данных о роли miR-142 в опухолевой прогрессии одного из самых частых лимфопролиферативных заболеваний – диффузной В-клеточной крупноклеточной лимфомы.МикроРНК miR-142 обладает широким спектром опухоль-супрессорных функций за счет нацеливания на ряд важнейших протоонкогенов, утрата контроля над которыми способствует усилению пролиферации, блоку апоптоза, активации сигнальных путей выживания В-лимфоцитов, метаболическому перепрограммированию, созданию иммуносупрессивной микросреды и избеганию опухолью иммунного надзора, а также диссеминации злокачественных клеток.Приведена информация о номенклатуре и механизмах образования miR-142, участии miR-142 в гемопоэзе, проанализированы патогенетическая роль miR-142 и взаимосвязь между профилем экспрессии miR-142 и диффузной В-клеточной крупноклеточной лимфомой, а также обсуждаются молекулярно-генетические нарушения miR-142 при данном заболевании.

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