OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press10310.17650/1818-8346-2011-6-1-35-38HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯThyroid function in children and adolescents after combined therapy of Hodgkin diseaseФункция щитовидной железы после комбинированной терапии болезни Ходжкина у детей и подростковFeoktistovR. I.ФеоктистовР. И.
Russian Federation
feoktistov-r@yandex.ruAbugovaY. G.АбуговаЮ. Г.
Russian Federation
DyakonovaY. Y.ДьяконоваЮ. Ю.
Russian Federation
MakarovaO. V.МакароваО. В.
Russian Federation
MyakovaN. V.МяковаН. В.
Russian Federation
Russian Children’s Clinical Hospital Federal Research Center of Pediatric Hematology, Oncology and ImmunologyРоссийская детская клиническая Российская больница ФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии Минздравсоцразвития РоссииRussian Children’s Clinical HospitalРоссийская детская клиническая Российская больница2402201161353824072014240720142011https://oncohematology.abvpress.ru/ongm/article/view/103

Thyroid diseases, especially hypothyroidism, are among the most frequent endocrine complications in patients with Hodgkin lymphoma whohave received neck irradiation. Thyroid function was evaluated in 34 patients (11 males and 23 females) after combined chemo radiotherapyof Hodgkin lymphoma according to modified DAL-HD-90M and GPOH-HD-2002 protocols. The median age was 15.9 years (range 5–18 years), the median time from the end of therapy was 1.08 years (range 1 month–4.9 years). 33 patients received radiotherapy to the neck region: 12 children — 20 Gy, 9 — 25 Gy, 10 — 30 Gy, 2 — 35 Gy. These patients were investigated by clinical examination, thyroid ultrasound and thyroid function tests. Thyroid abnormalities were detected in 4 of 21 patients who received 20–25 Gy (1 case of autoimmune thyroiditis and 3 cases of subclinical hypothyroidism) and in 3 of 12 patients who received 30–35 Gy (2 cases of autoimmune thyroiditis and 1 case of subclinical hypothyroidism). Autoimmune thyroiditis also developed in patient who received only 35 Gy mediastinum irradiation. Age, sex, follow-up time, irradiation dose were not significant factors in the thyroid dysfunction development. Thyroid examination must be obligatory part of the follow-up examination of patients with Hodgkin lymphoma.

childrenadolescentsHodgkin lymphomathyroid glandдетиподросткилимфома Ходжкинащитовидная железа1. Hoppe R.T., Mauch P.T., Armitage J.O. et al. Hodgkin Lymphoma. Lippincott Williams & Wilkins. Philadelphia, 2007.Hoppe R.T., Mauch P.T., Armitage J.O. et al. Hodgkin Lymphoma. Lippincott Williams & Wilkins. Philadelphia, 2007.2. Jereczek-Fossa B.A., Alterio D., Jassem J. et al. Radiotherapy-induced thyroid disorders. Cancer Treat Rev 2004;30(4):369–84.Jereczek-Fossa B.A., Alterio D., Jassem J. et al. Radiotherapy-induced thyroid disorders. Cancer Treat Rev 2004;30(4):369–84.3. Ильин Н.В., Виноградова Ю.Н. Поздние осложнения терапии больных лимфомой Ходжкина. Практич онкол 2007;8(2):96–101.Ильин Н.В., Виноградова Ю.Н. Поздние осложнения терапии больных лимфомой Ходжкина. Практич онкол 2007;8(2):96–101.4. Constine L.S., Donaldson S.S., McDougall I.R. et al. Thyroid dysfunction after radiotherapy in children with Hodgkin’s disease. Cancer 1984;53(4):878–83.Constine L.S., Donaldson S.S., McDougall I.R. et al. Thyroid dysfunction after radiotherapy in children with Hodgkin’s disease. Cancer 1984;53(4):878–83.5. Sklar C., Whitton J., Mertens A. et al. Abnormalities of the thyroid in survivors of Hodgkin’s disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 2000;85:3227–32.Sklar C., Whitton J., Mertens A. et al. Abnormalities of the thyroid in survivors of Hodgkin’s disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 2000;85:3227–32.6. Altman A.J. Supportive care of children with cancer. The Johns Hopkins University Press, Baltimore, 2004.Altman A.J. Supportive care of children with cancer. The Johns Hopkins University Press, Baltimore, 2004.7. Lanzkowsky P. Manual of Pediatric Hematology and Oncology. Elsevier academic press, 2005.Lanzkowsky P. Manual of Pediatric Hematology and Oncology. Elsevier academic press, 2005.8. Кияев А.В. Аутоиммунный тиреоидит у детей. Попробуем взглянуть поиному? Клинич и экспер тиреоидология 2008;4(3):23–7.Кияев А.В. Аутоиммунный тиреоидит у детей. Попробуем взглянуть поиному? Клинич и экспер тиреоидология 2008;4(3):23–7.9. Самочатова Е.В., Владимирская Е.Б., Жесткова Н.М. и др. Болезнь Ходжкина у детей. М.: Алтус, 1997.Самочатова Е.В., Владимирская Е.Б., Жесткова Н.М. и др. Болезнь Ходжкина у детей. М.: Алтус, 1997.10. Jaksic J., Dumic M., Filipovic B. et al. Thyroid disease in a school population with thyromegaly. Arch Dis Child 1994;70(2):103–6.Jaksic J., Dumic M., Filipovic B. et al. Thyroid disease in a school population with thyromegaly. Arch Dis Child 1994;70(2):103–6.11. Van Leeuwen F.E., Klokman W.J., Veer M.B. et al. Long-term risk of second malignancy in survivors of Hodgkin’s disease treated during adolescence or young adulthood. J Clin Oncol 2000;18(3):487–97.Van Leeuwen F.E., Klokman W.J., Veer M.B. et al. Long-term risk of second malignancy in survivors of Hodgkin’s disease treated during adolescence or young adulthood. J Clin Oncol 2000;18(3):487–97.12. Swerdlow A.J., Barber J.A., Hudson G.V. et al. Risk of second malignancy after Hodgkin’s disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 2000;18(3):498–509.Swerdlow A.J., Barber J.A., Hudson G.V. et al. Risk of second malignancy after Hodgkin’s disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 2000;18(3):498–509.