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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Oncohematology</journal-id><journal-title-group><journal-title xml:lang="en">Oncohematology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкогематология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1818-8346</issn><issn publication-format="electronic">2413-4023</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1016</article-id><article-id pub-id-type="doi">10.17650/1818-8346-2025-20-1-165-170</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>SUPPORTIVE THERAPY ASPECTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АСПЕКТЫ ПОДДЕРЖИВАЮЩЕЙ ТЕРАПИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Visual-motor function disorders in children who survived acute lymphoblastic leukemia and central nervous system tumors</article-title><trans-title-group xml:lang="ru"><trans-title>Нарушения зрительно-моторных функций у детей, переживших острый лимфобластный лейкоз и опухоли центральной нервной системы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7666-1089</contrib-id><name-alternatives><name xml:lang="en"><surname>Deviaterikova</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Девятерикова</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Alena Andreevna Deviaterikova</p><p>117198; 6 Miklukho-Maklaya St.; 117997; 1 Samory Mashela St.; Moscow</p></bio><bio xml:lang="ru"><p>Алена Андреевна Девятерикова</p><p>117198; ул. Миклухо-Маклая, 6; 117198;  ул. Саморы Машела, 1; Москва</p></bio><email>alena.deviaterikova@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия&#13;
Рогачева» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-03-19" publication-format="electronic"><day>19</day><month>03</month><year>2025</year></pub-date><volume>20</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>165</fpage><lpage>170</lpage><history><date date-type="received" iso-8601-date="2025-03-22"><day>22</day><month>03</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-03-22"><day>22</day><month>03</month><year>2025</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://oncohematology.abvpress.ru/ongm/article/view/1016">https://oncohematology.abvpress.ru/ongm/article/view/1016</self-uri><abstract xml:lang="en"><p><bold>   Background. </bold>Cancer and its treatment result in late effects of therapy. Some of them reduce the children quality of life and may affect their academic performance at school. One of such disorders, which 70–90 % of children who have survived cancer complain about, is visual‑motor dysfunctions.</p><p><bold>   Aim. </bold>To assess visual‑motor functions among children who have survived cancer.</p><p><bold>   Materials and methods. </bold>The study was conducted between September 2023 and September 2024. The study involved 105 children: 39 children who survived central nervous system tumors (23 (60 %) children with medulloblastoma and 16 (40 %) children with astrocytoma); 31 who survived acute lymphoblastic leukemia; 35 patients in the control group of healthy children. The average age of children was 12.2 (7–17) years.</p><p><bold>   Results. </bold>A statistically significant decrease in scores of visual‑motor functions, compared with the control group, was found in children who had survived central nervous system tumors (p &lt; 0.01) and acute lymphoblastic leukemia (p &lt; 0.01). In addition, the higher the score on the Common Terminology Criteria for Adverse Events (CTCAE) v.4.3 toxicity scale,the lower the scores of visual‑motor functions (p &lt; 0.01). In all study groups of children there was an increase in scores with age (p &lt; 0.01) – the older the child, the higher the scores.</p><p><bold>   Conclusion. </bold>Statistically significant impairments of visual‑motor functions were revealed in children who survived central nervous system tumors and acute lymphoblastic leukemia. These declines can later have a negative impact on learning, so they require additional rehabilitation measures aimed at restoring visual‑motor functions.</p></abstract><trans-abstract xml:lang="ru"><p><bold>   Введение. </bold>Онкологическое заболевание и его лечение сопровождаются отсроченными эффектами терапии. Часть из них снижает качество жизни детей и может повлиять на их успеваемость в школе. Одними из таких нарушений, на которые предъявляют жалобы 70–90 % детей, переживших онкологические заболевания, являются нарушения зрительно‑моторных функций.</p><p><bold>   Цель исследования</bold> – оценить состояние зрительно‑моторных функций среди детей, переживших онкологические заболевания.</p><p> <bold>  Материалы и методы. </bold>Исследование проведено в период с сентября 2023 г. по сентябрь 2024 г. В нем приняли участие 105 пациентов: 39 детей, пережившие опухоли центральной нервной системы (23 (60 %) – медуллобластому, 16 (40 %) – астроцитому); 31 – острый лимфобластный лейкоз; 35 – контрольная группа здоровых детей. Средний возраст участников составил 12,2 (7–17) года.</p><p><bold>   Результаты. </bold>Статистически значимое снижение показателей зрительно‑моторных функций по сравнению с контрольной группой выявлено у детей, переживших опухоли центральной нервной системы (p &lt; 0,01) и острый лимфобластный лейкоз (p &lt; 0,01). кроме того, чем выше балл по шкале токсичности Общих терминологических критериев для оценки нежелательных явлений (Common Terminology Criteria for Adverse Events, CTCAE) v.4.3, тем ниже показатели зрительно‑моторных функций (p &lt; 0,01). Во всех исследованных группах наблюдался рост показателей с возрастом (p &lt; 0,01): чем старше ребенок, тем выше показатели.</p><p><bold>   Заключение. </bold>У детей, переживших онкологические заболевания центральной нервной системы и острый лимфобластный лейкоз, выявлены статистически значимые нарушения зрительно‑моторных функций. Эти нарушения впоследствии могут оказывать отрицательное влияние на обучение, поэтому требуют дополнительных реабилитационных мероприятий, направленных на восстановление зрительно‑моторных функций.</p></trans-abstract><kwd-group xml:lang="en"><kwd>central nervous system tumor</kwd><kwd>acute lymphoblastic leukemia</kwd><kwd>visual‑motor skill</kwd><kwd>remission</kwd><kwd>late effect of treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>опухоль центральной нервной системы</kwd><kwd>острый лимфобластный лейкоз</kwd><kwd>зрительно‑моторный навык</kwd><kwd>ремиссия</kwd><kwd>отсроченный эффект лечения</kwd></kwd-group><funding-group><funding-statement xml:lang="en">This research was funded by the Russian Science Foundation (project No. 23­78­01117)</funding-statement><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке Российского научного фонда (грант № 23­78­01117)</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Malignant tumors in Russia in 2023 (morbidity and mortality). Eds.: А.D. Kaprin, V.V. Starinskiy, A.O. Shachzadova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2024. 276 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2023 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, А.О. Шахзадовой. 2024. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2024. 276 с.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Men T.Kh., Polyakov V.G., Aliev M.D. Epidemiology of childhood cancer in Russia. Onkopediatriya = Oncopediatrics 2014;1(1):7–12. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Мень Т.Х., Поляков В.Г., Алиев М.Д. Эпидемиология злокачественных новообразований у детей в России. Онкопедиатрия 2014;1(1):7–12.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Aleskerova G.A., Shervashidze M.A., Popa A.V. Treatment results of all IC­BFM 2002 protocol in children with acute lymphoblastic leukemia debating club. Onkopediatriya = Oncopediatrics 2016;3(4):302–8. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Алескерова Г.А., Шервашидзе М.А., Попа А.В. и др. Результа­ты лечения острого лимфобластного лейкоза у детей по прото­колу ALL IC­BFM 2002. Онкопедиатрия 2016;3(4):302–8.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><mixed-citation>Butler E., Ludwig K., Pacenta H.L. et al. Recent progress in the treatment of cancer in children. CA Cancer J Clin 2021;71(4):315–32. DOI: 10.3322/caac.21665</mixed-citation></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Gurieva O.D., Savelyeva M.I., Valiev T.T. Genetic basis of clinical variants of chemotherapy toxicity in children with acute lymphoblastic leukemia (literature review). Rossiyskiy zhurnal detskoy gematologii i onkologii = Russian Journal of Pediatric Hematology and Oncology 2021;8(4):60–70. (In Russ.). DOI: 10.21682/2311­1267­2021­8­4­60­70</mixed-citation><mixed-citation xml:lang="ru">Гурьева О.Д., Савельева М.И., Валиев Т.Т. Генетические основы клинических вариантов токсичности химиотерапии у детей с острым лимфобластным лейкозом (обзор литературы). Российский журнал детской гематологии и онкологии 2021;8(4):60–70. DOI: 10.21682/2311­1267­2021­8­4­60­70</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Bozhenko V.K., Radzhesh R., Riger A.N. et al. Antitumor vaccines. Literature review. Vestnik Rossiyskogo nauchnogo centra rentrenradiologii Minzdrava Rossii = Bulletin of the Russian Scientific Center of Roentgenoradiology 2022;22(4):99–126. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Боженко В.К., Раджеш Р., Ригер А.Н. и др. Противоопухолевые вакцины. Литературный обзор. Вестник Российского научного центра рентгенорадиологии Минздрава России 2022;22(4):99–126.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><mixed-citation>Ernst M., Hinz A., Brähler E. et al. Quality of life after pediatric cancer: comparison of long­term childhood cancer survivors’ quality of life with a representative general population sample and associations with physical health and risk indicators. Health Qual Life Outcomes 2023;21(1):65. DOI: 10.1186/s12955­023­02153­7</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>CureAll Framework: WHO Global Initiative for Childhood Cancer. World Health Organization, 2021.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Reddick W.E., Glass J.O., Palmer S.L. et al. Atypical white matter volume development in children following craniospinal irradiation. Neuro Oncol 2005;7(1):12–9. DOI: 10.1215/S1152851704000079</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Armstrong C., Sun L.R. Neurological complications of pediatric cancer [published correction appears in Cancer Metastasis Rev 2020;39(1):25]. Cancer Metastasis Rev 2020;39(1):3–23. DOI: 10.1007/s10555­020­09847­0</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Edelstein K., Spiegler B.J., Fung S. et al. Early aging in adult survivors of childhood medulloblastoma: long­term neurocognitive, functional, and physical outcomes. Neuro Oncol 2011;13(5): 536–45. DOI: 10.1093/neuonc/nor015</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Godono A., Felicetti F., Conti A. et al. Employment among childhood cancer survivors : a systematic review and meta­analysis. Cancers (Basel) 2022;14(19):4586. DOI: 10.3390/cancers14194586</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Demos­Davies K., Lawrence J., Seelig D. Cancer related cognitive impairment: a downside of cancer treatment. Front Oncol 2024;14:1387251. DOI: 10.3389/fonc.2024.1387251</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>L’Hotta A.J., Randolph S.B., Reader B. et al. Clinical practice guideline and expert consensus recommendations for rehabilitation among children with cancer : a systematic review. CA Cancer J Clin 2023;73(5):524–45. DOI: 10.3322/caac.21783</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Hanna S., El-­Ayadi M., Abdelazeim F. Identifying fine motor difficulties in children with acute lymphoblastic leukemia : a scoping review. Support Care Cancer 2024;32(7):488. DOI: 10.1007/s00520­024­08667­0</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Brito­Suárez J.M., Camacho­Juárez F., Sánchez­Medina C.M. et al. Gross motor disorders in pediatric patients with acute lymphoblastic leukemia and survivors : a systematic review. Pediatr Hematol Oncol 2022;39(7):658–71. DOI: 10.1080/08880018.2022.2045409</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Escolano­Pérez E., Herrero­-Nivela M.L., Losada J.L. Association between preschoolers’ specific fine (but not gross) motor skills and later academic competencies: educational implications. Front Psychol 2020;11:1044. DOI: 10.3389/fpsyg.2020.01044</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Beery K.E., Buktenica N.A. Developmental test of visual­motor integration: administration, scoring and teaching manual. Modern Curriculum Press, 1989.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Saatci D., Thomas A., Botting B., Sutcliffe A.G. Educational attainment in childhood cancer survivors: a meta­analysis. Arch Dis Child 2020;105(4):339–46. DOI: 10.1136/archdischild­2019­317594</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Sleurs C., Lemiere J., Vercruysse G. et al. Rehabilitation in pediatric oncology. Belg J Paediatr 2021;23(1):35–8.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Oswald K.A., Bo J. Motor functioning and associated cognitive outcomes in pediatric survivors of acute lymphoblastic leukemia. Child Neuropsychol 2020;26(5):597–611. DOI: 10.1080/09297049.2019.1676406</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Levitch C.F., Holland A.A., Bledsoe J. et al. Comparison of neuropsychological functioning in pediatric posterior fossa tumor survivors: medulloblastoma, low‐grade astrocytoma, and healthy controls. Pediatr Blood Cancer 2022;69(2):e29491. DOI: 10.1093/neuonc/noac079.494</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Van de Velde M.E., Kaspers G.L., Abbink F.C.H. et al. Vincristine-induced peripheral neuropathy in children with cancer : a systematic review. Crit Rev Oncol Hematol 2017;114:114–30. DOI: 10.1016/j.critrevonc.2017.04.004</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Bledsoe J.C., Breiger D., Breiger M. et al. Differential trajectories of neurocognitive functioning in females versus males following treatment for pediatric brain tumors. Neuro Oncol 2019;21(10):1310–8. DOI: 10.1093/neuonc/noz092</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Peterson R.K., Chen Y., Oeffinger K. et al. The impact of sex and associations with treatment exposures on neurocognitive impairment in pediatric cancer survivors: a report from the childhood cancer survivor study. J Int Neuropsychol Soc 2023;29(s1):315–6. DOI: 10.1017/s1355617723004368</mixed-citation></ref></ref-list></back></article>
