OncohematologyOncohematologyОнкогематология1818-83462413-4023Publishing House ABV Press10010.17650/1818-8346-2011-6-1-11-19HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CAREГЕМОБЛАСТОЗЫ: ДИАГНОСТИКА, ЛЕЧЕНИЕ, СОПРОВОДИТЕЛЬНАЯ ТЕРАПИЯClinical and genetic characteristics of acute myeloid leukemia with t(8;21) in children and results of therapy according to protocol AML-MM-2000Клинические и генетические особенности острого миелоидного лейкоза с t(8;21) у детей и результаты терапии по протоколу ОМЛ-ММ-2000KalininaI. I.КалининаИ. И.
Russian Federation
burbir@mail.ruShneyderM. M.ШнейдерМ. М.
Russian Federation
KirsanovaN. P.КирсановаН. П.
Russian Federation
BaydildinaD. D.БайдильдинаД. Д.
Russian Federation
SuntsovaE. V.СунцоваЕ. В.
Russian Federation
GoronkovaO. V.ГоронковаО. В.
Russian Federation
KhachatryanL. A.ХачатрянЛ. А.
Russian Federation
NovichkovaG. A.НовичковаГ. А.
Russian Federation
MaschanM. A.МасчанМ. А.
Russian Federation
YutskevichR. I.ЮцкевичР. И.
Russian Federation
VolochnikE. V.ВолочникЕ. В.
Russian Federation
SavitskayaT. V.СавицкаяТ. В.
Russian Federation
MinakovskayaN. V.МинаковскаяН. В.
Russian Federation
ProleskovskayaI. V.ПролесковскаяИ. В.
Russian Federation
EmelyanovaI. V.ЕмельяноваИ. В.
Russian Federation
KarasO. V.КарасьО. В.
Russian Federation
MigalN. V.МигальН. В.
Russian Federation
MareykoYu. E.МарейкоЕ. Ю.
Russian Federation
DrekovA. G.ДрековА. Г.
Russian Federation
RumyantsevaJ. V.РумянцеваЮ. В.
Russian Federation
FleyshmanE. V.ФлейшманЕ. В.
Russian Federation
NasedkinaT. V.НаседкинаТ. В.
Russian Federation
AleynikovaO. V.АлейниковаО. В.
Russian Federation
MaschanA. A.МасчанА. А.
Russian Federation
Federal Research Center of Pediatric Hematology, Oncology and ImmunologyФедеральный научно-клинический центр детской гематологии, онкологии Федеральный и иммунологии Минздравсоцразвития РоссииRepublic Center of Pediatric Oncology and HematologyРеспубликанский научно-практический центр детской онкологии и гематологииInstitute of Cancerogenesis, N.N. Blokhin Cancer Research Center, Russian Academy of Medical SciencesНИИ канцерогенеза РОНЦ им. Н.Н. Блохина РАМНEngelhardt Institute of Molecular Biology, Russian Academy of SciencesИнститут молекулярной биологии им. В.А. Энгельгардта РАН2402201161111923072014230720142011https://oncohematology.abvpress.ru/ongm/article/view/100

A t(8;21) is the most frequent abnormality in AML in children. Patients with this genetic abnormality are traditionally expected favorable prognosis with a probability of cure up to 80 %. Known additional cytogenetic abnormalities in AML with t(8;21) not affecting prognosis. These include loss of one sex chromosome and del(9q-). Prognosis impact of additional abnormalities involving chromosomes 7 and 11 in patients with t(8;21) is unknown. The purpose of this study was to analyse of additional anomalies, that occur in patients with t(8;21), and their influence on prognosis. During the study period 173 children with AML have received AML-MM-2000 treatment protocol in Russia and Belarus. Of these, in 33 patients (11 girls and 22 boys, median age — 10.5 years) t(8;21) was detected by chromosome banding or molecular-genetic analysis. In group with t(8;21) CNS leukemia in 8 patients was detected, extramedullary lesion — in 8 patients. In 4 patients CNS leukemia combined with presence of extramedullary lesions. These factors did not influence on therapy outcome. Overall survival of AML patients with t(8;21) was 0,67 ± 0,08 compared to 0,44 ± 0,04 in patients with AML without this translocation (p = 0,04). Special subgroup consist of 5 patients with t(8;21) and identified chromosomal abnormalities affecting chromosome 7 and 11, which were a poor prognostic factor: event-free survival in this subgroup of patients (n = 5) was 0,0 ± 0,0, compared to 0,34 ± 0,16 in patients with t(8;21) without additional anomalies (n = 28) (p = 0,027).

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