Pediatric follicular lymphoma: literature review and presentation of a rare clinical case

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Abstract

Follicular lymphoma is one of the most common non-Hodgkin’s lymphomas in adults. One of the rather rare variants of follicular lymphoma is pediatric follicular lymphoma. This variant, despite the name, is diagnosed not only in children, but also among young adults. Pediatric follicular lymphoma is characterized by early (I, II) stages, the absence or weak BCL2 expression, and the predominant absence of t(14;18)(q32;q21) translocation. Treatment tactics vary widely from radical surgical tumor resection with subsequent follow-up to chemoimmunotherapy with rituximab.

This article presents a clinical case of advanced pediatric follicular lymphoma (stage III) in a 5-year-old patient. Using a combined treatment approach (surgery followed by immunochemotherapy) allowed to achieve a complete metabolic response which lasts more than a year.

About the authors

A. S. Volkova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-1709-0498

23 Kashirskoe Shosse, Moscow 115522

Russian Federation

T. T. Valiev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Author for correspondence.
Email: timurvaliev@mail.ru
ORCID iD: 0000-0002-1469-2365

Timur T. Valiev 

23 Kashirskoe Shosse, Moscow 115522,

Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

D. S. Abramov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

ORCID iD: 0000-0003-3664-2876

1 Samory Mashela St., Moscow 117197

Russian Federation

A. V. Tarakanova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia

ORCID iD: 0000-0002-9496-3136

1 Samory Mashela St., Moscow 117197

Russian Federation

A. A. Odzharova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

23 Kashirskoe Shosse, Moscow 115522

Russian Federation

Yu. E. Ryabukhina

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0001-8443-8816

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

P. A. Zeynalova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University);
Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0003-1564-424X

Build. 2, 8 Trubetskaya St., Moscow 119991,

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

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