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Detection of 11q23 (MLL) rearrangements in infant acute lymphoblastic leukemia
- Authors: Tsaur G.A.1, Popov A.M.1, Aleynikova O.V.2, Boychenko E.G.3, Verzhbitskaya T.Y.1, Volochnik E.V.2, Ivanova A.S.1, Kalennik O.V.4, Kovalev S.Y.5, Kondtratchik K.L.6, Kustanovich A.M.2, Lapotentova E.S.2, Litvinov D.V.7, Martynkevich I.S.8, Myakova N.V.7, Nasedkina T.V.4, Ovsepyan V.A.9, Olshanskaya Y.V.7, Plehanova O.M.10, Popa A.V.11, Riger T.O.1, Savelyev L.I.12, Streneva O.V.1, Strigaleva M.V.10, Shmunk I.V.13, Shorikov E.V.1, Fechina L.G.1
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Affiliations:
- Regional Children’s Hospital № 1 Research Institute of Medical Cell Technologies
- Belarusian Research Center for Pediatric Oncology and Hematology
- Children’s Municipal Hospital № 1
- Engelgardt Institute of Molecular Biology Russian Academy of Science
- B. Eltsyn Ural Federal University
- Morozov Pediatric Municipal Clinical Hospital
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
- Russian Research Institute of Hematology and Transfusiology
- Kirov Research Institute of Hematology and Transfusiology
- Regional Children’s Hospital № 1
- Ural State Medical Academy
- Regional Children’s Hospital № 1 Research Institute of Medical Cell Technologies Ural State Medical Academy
- Chelyabinsk Regional Blood Transfusion Station
- Issue: Vol 6, No 3 (2011)
- Pages: 57-64
- Section: BASIC RESEARCH
- Published: 23.08.2011
- URL: https://oncohematology.abvpress.ru/ongm/article/view/91
- DOI: https://doi.org/10.17650/1818-8346-2011-6-3-57-64
- ID: 91
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Abstract
117 cases of infant acute lymphoblastic leukemia without Down syndrome (aged from 1 to 365 days) were included in the current study.
Rearrangements of 11q23 (MLL) were revealed in 74 (63.2 %) patients. Among this group the most common rearrangement was t(4;11) q21;q23)/MLL-AF4 detected in 63.5 % cases, less frequently was found t(11;19)(q23;p13)/MLL-MLLT1 (in 18.9 % cases), t(10;11) p12;q23)/MLL-MLLT10 and t(1;11)(p32;q23)/ML L-EPS15 (each one in 6.8 %), t(9;11)(p22;q23)/MLL-MLLT3 in 2.7 %. Children under 6 months of age had significantly higher incidence of 11q23 (ML L) rearrangements in comparison with infants olde r than 6 months (84.0 % vs. 47.8 %, p < 0.001). P atients with translocations 11q23 (ML L) more frequently had BI-A LL and less frequently BII-ALL than children without these rearrangements (p < 0.001 f or both). Fusion gene transcript w as sequenced in 26 ML Lrearranged cases. Depending on breakpoint position within ML L and partner genes we detected 7 differ ent types of ML L-AF4 fusion gene transcript, 3 types of MLL-MLLT1, 2 types of MLL-EPS15. The most common fusion site within MLL gene was exon 11, detected in 14 (53.8 %) patients.
About the authors
G. A. Tsaur
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Author for correspondence.
Email: tsaur@mail.ru
Russian Federation
A. M. Popov
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Russian Federation
O. V. Aleynikova
Belarusian Research Center for Pediatric Oncology and HematologyRussian Federation
E. G. Boychenko
Children’s Municipal Hospital № 1Russian Federation
T. Yu. Verzhbitskaya
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Russian Federation
E. V. Volochnik
Belarusian Research Center for Pediatric Oncology and HematologyRussian Federation
A. S. Ivanova
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Russian Federation
O. V. Kalennik
Engelgardt Institute of Molecular Biology Russian Academy of ScienceRussian Federation
S. Yu. Kovalev
B. Eltsyn Ural Federal UniversityRussian Federation
K. L. Kondtratchik
Morozov Pediatric Municipal Clinical HospitalRussian Federation
A. M. Kustanovich
Belarusian Research Center for Pediatric Oncology and HematologyRussian Federation
E. S. Lapotentova
Belarusian Research Center for Pediatric Oncology and HematologyRussian Federation
D. V. Litvinov
Federal Research Institute of Pediatric Hematology, Oncology and ImmunologyRussian Federation
I. S. Martynkevich
Russian Research Institute of Hematology and TransfusiologyRussian Federation
N. V. Myakova
Federal Research Institute of Pediatric Hematology, Oncology and ImmunologyRussian Federation
T. V. Nasedkina
Engelgardt Institute of Molecular Biology Russian Academy of ScienceRussian Federation
V. A. Ovsepyan
Kirov Research Institute of Hematology and TransfusiologyRussian Federation
Yu. V. Olshanskaya
Federal Research Institute of Pediatric Hematology, Oncology and ImmunologyRussian Federation
O. M. Plehanova
Regional Children’s Hospital № 1Russian Federation
A. V. Popa
Ural State Medical AcademyRussian Federation
T. O. Riger
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Russian Federation
L. I. Savelyev
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Ural State Medical Academy
Russian Federation
O. V. Streneva
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Russian Federation
M. V. Strigaleva
Regional Children’s Hospital № 1Russian Federation
I. V. Shmunk
Chelyabinsk Regional Blood Transfusion StationRussian Federation
E. V. Shorikov
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Russian Federation
L. G. Fechina
Regional Children’s Hospital № 1Research Institute of Medical Cell Technologies
Russian Federation
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