Prognostic model and risk factors for hospital mortality in patients with diffuse large B-cell lymphoma associated with coronavirus infection: a single-center cohort study

Yu. Yu. Polyakov; Поляков Ю. Ю.; E. A. Baryakh; Барях Е. А.; E. N. Misyurina; Мисюрина Е. Н.; E. I. Zhelnova; Желнова Е. И.; K. V. Yatskov; Яцков К. В.; A. B. Makeshova; Макешова А. Б.; M. A. Mingalimov; Мингалимов М. А.; T. N. Tolstykh; Толстых Т. Н.; T. S. Chudnova; Чуднова Т. С.; D. D. Ivanova; Иванова Д. Д.; A. I. Koneva; Конева А. И.; O. L. Kochneva; Кочнева О. Л.; E. N. Zotina; Зотина Е. Н.; D. E. Gagloeva; Гаглоева Д. Э.; E. Yu. Grishina; Гришина Е. Ю.; L. T. Shimanovskaya; Шимановская Л. Т.; V. N. Yakimets; Якимец В. Н.

doi:10.17650/1818-8346-2023-18-4(Suppl)-74-85

Prognostic model and risk factors for hospital mortality in patients with diffuse large B-cell lymphoma associated with coronavirus infection: a single-center cohort study

Authors: Polyakov Y.Y.¹^,2, Baryakh E.A.¹^,2^,3^,4, Misyurina E.N.¹^,2, Zhelnova E.I.¹^,2, Yatskov K.V.¹, Makeshova A.B.¹^,2, Mingalimov M.A.¹^,2, Tolstykh T.N.¹^,2, Chudnova T.S.¹^,2, Ivanova D.D.¹, Koneva A.I.¹, Kochneva O.L.¹, Zotina E.N.¹^,2, Gagloeva D.E.¹^,2, Grishina E.Y.¹, Shimanovskaya L.T.¹, Yakimets V.N.¹
Affiliations:
1. City Clinical Hospital No. 52, Moscow Healthcare Department
2. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
3. Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
4. N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Issue: Vol 18, No 4 (2023): Supplement
Pages: 74-85
Section: Articles
Published: 15.01.2024
URL: https://oncohematology.abvpress.ru/ongm/article/view/893
DOI: https://doi.org/10.17650/1818-8346-2023-18-4(Suppl)-74-85
ID: 893

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Abstract

Background. Coronavirus disease (COVID-19), caused by SARS-CoV-2, presents new challenges to hematologists, highlighting the vulnerability of patients with hematological malignancies, in particular with diffuse large B-cell lymphoma (DLBCL). Identification of hospital mortality risk factors is necessary for subsequent stratification of patients into risk groups, which will allow further risk-based therapy.

Aim. To develop a prognostic model and identify risk factors for hospital mortality in patients with DLBCL associated with COVID-19.

Materials and methods. The interim retrospective study included 112 patients with an immunohistochemically confirmed diagnosis of DLBCL, coronavirus infection verified based on polymerase chain reaction (PCR) for SARS-CoV-2, and viral pneumonia associated with COVID-19. To determine the risk factors for hospital mortality, a multivariate (logistic regression) statistical analysis was performed. The study end point was a binary variable - the patient vital status (discharged alive or died).

Results and conclusion. Of the 112 patients, 24 died. Due to the limited number of patients compared to the number of predictors and to avoid overfitting, a two-stage approach to constructing a predictive model was used. In univariate analysis, statistically significant during hospitalization were the hematological disease status (complete remission/partial remission, progression/relapse, de novo), positive PCR result, C-reactive protein level >6 mg/L, platelets <100 thousand/pL, hemoglobin <120 g/L, albumin <35 g/L, lactate dehydrogenase >248 U/L, D-dimer >500 ng/mL and the degree of lung tissue damage according to computed tomography >50 % (grade II and above), respiratory failure I degrees and higher. The final model was constructed by minimizing the Akaike information criterion. The final model included a positive PCR result, stage II respiratory failure, hematologic disease status (relapse/progression), and albumin level at the time of hospital admission.

Keywords

prognostic model, hospital mortality, diffuse large B-cell lymphoma, coronavirus infection

About the authors

Yu. Yu. Polyakov

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Author for correspondence.
Email: yurij.polyakov86@yandex.ru
ORCID iD: 0009-0007-8389-6269

Yuriy Yu. Polyakov.

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. A. Baryakh

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

ORCID iD: 0000-0001-6880-9269

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991; Build. 1, 2 / 1 Barrikadnaya St., Moscow 125993; 1 Ostrovityanova St., Moscow 117997

Russian Federation

E. N. Misyurina

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0003-2419-4850

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. I. Zhelnova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-0343-9348

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

K. V. Yatskov

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0000-0003-0125-9068

3 Pekhotnaya St., Moscow 123182

Russian Federation

A. B. Makeshova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-0414-2554

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

M. A. Mingalimov

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8491-2140

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

T. N. Tolstykh

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-7308-0927

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

T. S. Chudnova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8012-1640

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

D. D. Ivanova

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0009-0004-3632-9198

3 Pekhotnaya St., Moscow 123182

Russian Federation

A. I. Koneva

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0009-0000-0569-0838

3 Pekhotnaya St., Moscow 123182

Russian Federation

O. L. Kochneva

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0000-0003-1338-8203

3 Pekhotnaya St., Moscow 123182

Russian Federation

E. N. Zotina

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-9692-2541

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

D. E. Gagloeva

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-6254-5362

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation