Treatment experience of coronavirus infection associated with SARS-CoV-2 in patients with acute myeloid leukemia in the older age group

L. T. Shimanovskaya; Шимановская Л. Т.; E. N. Misyurina; Мисюрина Е. Н.; E. A. Baryakh; Барях Е. А.; E. I. Zhelnova; Желнова Е. И.; K. V. Yatskov; Яцков К. В.; T. S. Chudnova; Чуднова Т. С.; A. B. Makeshova; Макешова А. Б.; M. A. Mingalimov; Мингалимов М. А.; D. D. Ivanova; Иванова Д. Д.; O. L. Kochneva; Кочнева О. Л.; E. N. Zotina; Зотина Е. Н.; T. N. Tolstykh; Толстых Т. Н.; E. Yu. Grishina; Гришина Е. Ю.; D. E. Gagloeva; Гаглоева Д. Э.; Yu. Yu. Polyakov; Поляков Ю. Ю.; V. N. Yakimets; Якимец В. Н.; A. I. Koneva; Конева А. И.

doi:10.17650/1818-8346-2023-18-4(Suppl)-53-63

Treatment experience of coronavirus infection associated with SARS-CoV-2 in patients with acute myeloid leukemia in the older age group

Authors: Shimanovskaya L.T.¹, Misyurina E.N.¹^,2, Baryakh E.A.¹^,2^,3^,4, Zhelnova E.I.¹^,2, Yatskov K.V.¹, Chudnova T.S.¹^,2, Makeshova A.B.¹^,2, Mingalimov M.A.¹^,2, Ivanova D.D.¹, Kochneva O.L.¹, Zotina E.N.¹^,2, Tolstykh T.N.¹^,2, Grishina E.Y.¹, Gagloeva D.E.¹^,2, Polyakov Y.Y.¹^,2, Yakimets V.N.¹, Koneva A.I.¹
Affiliations:
1. City Clinical Hospital No. 52, Moscow Healthcare Department
2. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
3. Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
4. N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Issue: Vol 18, No 4 (2023): Supplement
Pages: 53-63
Section: Articles
Published: 15.01.2024
URL: https://oncohematology.abvpress.ru/ongm/article/view/892
DOI: https://doi.org/10.17650/1818-8346-2023-18-4(Suppl)-53-63
ID: 892

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

Aim. To study the course of COVID-19 (COronaVIrus Disease 2019) in elderly patients with acute myeloid leukemia (AML), to analyze risk factors for unfavorable outcome.

Materials and methods. The paper presents our own experience in the treatment of elderly (age ≥65 years) patients with AML and concomitant coronavirus infection in the hematology departments of City Clinical Hospital No. 52 (Moscow) from March 2020 to June 2022. The diagnosis of COVID-19 was considered confirmed based on a positive result of the polymerase chain reaction of an oropharyngeal and nasopharyngeal swab for SARS-CoV-2 and/or a typical radiological picture on a computed tomogram of the lungs.

Results. An analysis of clinical, laboratory and instrumental data of 59 patients (30 (51 %) men, 29 (49 %) women) with AML and COVID-19 was carried out. All patients were treated for COVID-19 in accordance with the Temporary guidelines “Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)” of the Russian Ministry of Health. Median age was 71 (65-91) years. AML was first verified in 27 % of hospitalized patients; 12 % were in remission of the disease. A month before hospitalization, 36 % of patients received antitumor therapy, and 19 % of patients had refractory AML. 17 % of hospitalized patients received antitumor therapy with cytarabine in small doses for vital indications. Death was recorded in 64 % of cases, in 24 % the cause of death was severe COVID-19. The unfavorable outcome was influenced by addition of secondary bacterial flora, refractory AML course and elderly age of patients.

Conclusion. Pre-exposure prophylaxis with monoclonal antibodies and vaccination of patients may be the main methods of preventing infection and severe course of COVID-19.

Keywords

acute myeloid leukemia in the elderly, coronavirus infection, COVID-19, infectious complication

About the authors

L. T. Shimanovskaya

City Clinical Hospital No. 52, Moscow Healthcare Department

Author for correspondence.
Email: vagizova2016@list.ru
ORCID iD: 0000-0002-9401-7991

Liliya T. Shimanovskaya.

3 Pekhotnaya St., Moscow 123182

Russian Federation

E. N. Misyurina

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0003-2419-4850

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. A. Baryakh

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

ORCID iD: 0000-0001-6880-9269

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991; Build. 1, 2 / 1 Barrikadnaya St., Moscow 125993; 1 Ostrovityanova St., Moscow 117997

Russian Federation

E. I. Zhelnova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-0343-9348

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

K. V. Yatskov

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0000-0003-0125-9068

3 Pekhotnaya St., Moscow 123182

Russian Federation

T. S. Chudnova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8012-1640

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

A. B. Makeshova

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-0414-2554

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

M. A. Mingalimov

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0002-8491-2140

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

D. D. Ivanova

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0009-0004-3632-9198

3 Pekhotnaya St., Moscow 123182

Russian Federation

O. L. Kochneva

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0000-0003-1338-8203

3 Pekhotnaya St., Moscow 123182

Russian Federation

E. N. Zotina

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-9692-2541

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

T. N. Tolstykh

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-7308-0927

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. Yu. Grishina

City Clinical Hospital No. 52, Moscow Healthcare Department

ORCID iD: 0000-0002-9104-1216

3 Pekhotnaya St., Moscow 123182

Russian Federation

D. E. Gagloeva

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0001-6254-5362

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

Yu. Yu. Polyakov

City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0009-0007-8389-6269

3 Pekhotnaya St., Moscow 123182; Build. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation