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Results of candidemia treatment in children with hematologic malignancies: single center experience
- Authors: Kalinina I.I.1, Baydildina D.D.1, Suntsova E.V.1, Goronkova O.V.2, Khachatryan L.A.1, Petrova U.N.1, Solopova G.G.1, Sinitsina V.V.1, Novichkova G.A.1, Maschan M.A.1, Litvinov D.V.3, Myakova N.V.3, Klyasova G.A.4, Maschan A.A.1
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Affiliations:
- Federal Research Center of Children Hematology, Oncology and Immunology
- Russian Children Clinical Hospital
- Federal Research Center of Children Hematology, Oncology and Immunology Russian Children Clinical Hospital
- Russian Hematological Research Center
- Issue: Vol 6, No 3 (2011)
- Pages: 24-34
- Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
- Published: 23.08.2011
- URL: https://oncohematology.abvpress.ru/ongm/article/view/87
- DOI: https://doi.org/10.17650/1818-8346-2011-6-3-24-34
- ID: 87
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Abstract
Candidemia is one of the most serious infectious complications in children with hematological malignancies and has a high morta lity rate.
Seven-year experience of candidemia diagnosis and therapy in patients with various hematologic malignancies w as analyzed. Candidemia registered in 37 patients (AML and MDS — 14, ALL — 10, solid tumors — 5, histocytic syndromes — 4, AA — 3, other non-malignancy diseases— 2). C. non-albicans (36 isolates from 32 patients) was common cause of, while C. albicans isolated in 5 patients (8 strains). Antifungal prophylactic therapy was applied to 31 patients. 22 patients at the time of candidemia have neutropenia (< 0.5 × 10 9/l). Main clinical manifestations were febrile fever (100 % cases) and pneumonia (21.6 % cases). Less frequent multiorgan failure (8.1 %), septic shoc k (5.4 %), chronic disseminated candidiasis (5.4 %) and meningitis (2.7 %) were registered. All patients received antifungal therapy (monotherapy — 17, combination therapy — 20). Central venous catheter removed in 21 patients. In 14 patients hematopoietic recovery w as registered, none of these patients died, while from group of patients without hematopoietic recovery 6 patients died (p = 0.0001). Recurrent candidemia episodes were seen in 4 patients. Overall survival was 0.37 ± 0.09.
About the authors
I. I. Kalinina
Federal Research Center of Children Hematology, Oncology and Immunology
Author for correspondence.
Email: burbir@mail.ru
Russian Federation
D. D. Baydildina
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
E. V. Suntsova
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
O. V. Goronkova
Russian Children Clinical HospitalRussian Federation
L. A. Khachatryan
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
U. N. Petrova
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
G. G. Solopova
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
V. V. Sinitsina
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
G. A. Novichkova
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
M. A. Maschan
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
D. V. Litvinov
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Children Clinical Hospital
Russian Federation
N. V. Myakova
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Children Clinical Hospital
Russian Federation
G. A. Klyasova
Russian Hematological Research CenterRussian Federation
A. A. Maschan
Federal Research Center of Children Hematology, Oncology and ImmunologyRussian Federation
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