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Resting energy expenditure and body composition in children with cancer: indirect calorimetry and bioimpedance analysis
- Authors: Konovalova M.V.1, Rudnev S.G.2, Tseytlin G.Y.1, Vashura A.Y.1, Starunova O.A.3, Nikolaev D.V.3
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Affiliations:
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia
- Institute of Numerical Mathematics, Russian Academy of Sciences
- Scientific Technical Centre “Medas”
- Issue: Vol 9, No 1 (2014)
- Pages: 25-34
- Section: HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Published: 21.07.2014
- URL: https://oncohematology.abvpress.ru/ongm/article/view/8
- DOI: https://doi.org/10.17650/1818-8346-2014-9-1-25-34
- ID: 8
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Abstract
Resting energy expenditure (REE) by indirect calorimetry and body composition by bioimpedance analysis are studied in three groups of children aged 5–18 years. Group 1 (n = 181) – patients in remission of cancer, group 2 (n = 55) – children with oncology diseases receiving chemotherapy or who are in the early period after hematopoietic stem cell transplantation, group 3 (n = 63) – children with non-malignant diseases of the gastrointestinal tract. To eliminate the influence of age and gender on the intergroup comparisons, body composition parameters were expressed as standardized values (z-scores) relative to a reference group of healthy Russian children (n = 138,191). Group 1 was characterized by excess fat content with intact lean body mass, and groups 2 and 3 by protein depletion, more pronounced in Group 2 with a higher percentage of body fat. All used conventional formulas (WHO, Harris–Benedict and others) in groups 1 and 3 underestimated REE as compared with indirect calorimetry. A new formula for REE, giving an unbiased estimate in the group 1 was proposed: REE (kcal/day) = 28.7 × BCM (kg) +10.5 × Height (cm) – 38.6 × Age (years) – 134, where BCM – body cell mass according to bioimpedance analysis (R2 = 0.67, the standard deviation of 196 kcal/day).
About the authors
M. V. Konovalova
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaRussian Federation
S. G. Rudnev
Institute of Numerical Mathematics, Russian Academy of SciencesRussian Federation
G. Ya. Tseytlin
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia
Author for correspondence.
Email: grigoryts@yandex.ru
Russian Federation
A. Yu. Vashura
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaRussian Federation
O. A. Starunova
Scientific Technical Centre “Medas”Russian Federation
D. V. Nikolaev
Scientific Technical Centre “Medas”Russian Federation
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