Features of acute megakaryoblastic leukemia diagnosis in a child with Down syndrome

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Abstract

We present a description of the difficulties in diagnosing acute megakaryoblastic leukemia in a child with Down syndrome aggravated by multiple comorbidities. In this case, a comprehensive assessment of clinical data, the results of an automatic complete blood count with a detailed interpretation of the entire range of parameters, as well as morphological and immunophenotypic bone marrow examination using an extended panel of monoclonal antibodies played a key role in the diagnosis.

About the authors

N. K. Guskova

National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: guskova.nailya@mail.ru
ORCID iD: 0000-0002-4222-1579

Nailya Katifovna Guskova

344037, Rostov-on-Don, 14th Liniya, 63

Russian Federation

O. N. Selyutina

National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0001-6762-0835

344037, Rostov-on-Don, 14th Liniya, 63

Russian Federation

I. B. Lysenko

National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-4457-3815

344037, Rostov-on-Don, 14th Liniya, 63

Russian Federation

Yu. Yu. Kozel

National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-6681-3253

344037, Rostov-on-Don, 14th Liniya, 63

Russian Federation

O. V. Kozyuk

National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-0676-7398

344037, Rostov-on-Don, 14th Liniya, 63

Russian Federation

V. V. Dmitrieva

National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-2124-3218

344037, Rostov-on-Don, 14th Liniya, 63

Russian Federation

M. A. Baranenkova

Rostov State Medical University, Ministry of Health of Russia

344022, Rostov-on-Don, Nakhichevanskiy Pereulok, 29

Russian Federation

A. S. Nozdricheva

National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-3336-9202

344037, Rostov-on-Don, 14th Liniya, 63

Russian Federation

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