Comparative characteristics of healthy newborns cord blood cell composition and G-SCF-mobilized blood from healthy donors

R. Sh. Ibragimov; Ибрагимов Р. Ш.; E. V. Raikina; Райкина Е. В.; E. Yu. Osipova; Осипова Е. Ю.; N. N. Zimina; Зимина Н. Н.; O. A. Maiorova; Майорова О. А.; M. V. Yakovleva; Яковлева М. В.; S. A. Roumiantsev; Румянцев С. А.

doi:10.17650/1818-8346-2009-0-4-45-50

Comparative characteristics of healthy newborns cord blood cell composition and G-SCF-mobilized blood from healthy donors

Authors: Ibragimov R.S.¹, Raikina E.V.¹^,2, Osipova E.Y.¹^,2, Zimina N.N.³, Maiorova O.A.¹, Yakovleva M.V.², Roumiantsev S.A.¹^,2
Affiliations:
1. Federal research center of pediatric hematology, oncology and immunology
2. Moscow Stem cells bank
3. Moscow Center of family planning and reproduction
Issue: No 4 (2009)
Pages: 45-50
Section: ФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ
Published: 28.11.2009
URL: https://oncohematology.abvpress.ru/ongm/article/view/785
DOI: https://doi.org/10.17650/1818-8346-2009-0-4-45-50
ID: 785

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Abstract

^{Cord blood cell composition is a short-lasting delivery stress consequence and is similar on adult G-CSF-mobilized peripheral blood.}

^{G-CSF realizes biological effect by number of secondary messengers, many of which are also natural effectors of stress. In this research comparative characteristics of cell composition, including lymphocytes subpopulations, CD34+ and CD133+ cells, hematopoietic progenitor cells colony-forming activity and mobilizing cytokines concentration (IL-8, MMP-2, MMP-9), between term newborns cord blood and G-CSF-mobilized peripheral blood is shown.}

^{Mobilized cytokines concentration ratio in combination with CD34+ cells count in cord blood and mobilized peripheral blood suggests that delivery stress possibly is not single cause of cord blood features}^.