Combination of multiple myeloma and chronic idiopathic myelofibrosis: a case report

N. A. Romanenko; Романенко Н. А.; S. S. Bessmeltsev; Бессмельцев С. С.; V. I. Rugal; Ругаль В. И.; N. A. Potichonova; Потихонова Н. А.; M. N. Zenina; Зенина М. Н.; K. M. Abdulkadirov; Абдулкадыров К. М.

doi:10.17650/1818-8346-2009-0-3-61-68

Combination of multiple myeloma and chronic idiopathic myelofibrosis: a case report

Authors: Romanenko N.A.¹, Bessmeltsev S.S.¹, Rugal V.I.¹, Potichonova N.A.¹, Zenina M.N.¹, Abdulkadirov K.M.¹
Affiliations:
1. Russian Research Institute of Hematology and Transfusiology
Issue: No 3 (2009)
Pages: 61-68
Section: HEMATOLOGIC MALIGNANCIES: TREATMENT, SUPPORTIVE CARE
Published: 27.08.2009
URL: https://oncohematology.abvpress.ru/ongm/article/view/778
DOI: https://doi.org/10.17650/1818-8346-2009-0-3-61-68
ID: 778

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Abstract

Case report of a patient with simultaneously developed lymphoid and myeloid hemoblastosis is presented. Diagnosis of multiple myeloma and chronic idiopathic myelofibrosis are confirmed by complete blood count, myelogramm, trephinebiopsy, immunohistochemical, cytogenetic, biochemical and radiological examination. Complete remission of multiple myeloma was achieved after 7 courses «VAD» and 11-weeks treatment with recombinant erythropoietin beta with subsequent maintenance therapy courses of bortezomib and reaferon. However, chronic idiopathic myelofibrosis was progressed to acute myeloid leukemia. Disease stabilization was achieved with 3 therapy courses «5+2».