Email this article 
Fullerene and oxidative stress
- Authors: Orlova M.A.1, Trofimova T.P.1, Orlov A.P.2, Shatalov O.A.3, Svistunov A.A.3, Napolov Y.K.3, Chekhonin V.P.2
-
Affiliations:
- M.V. Lomonosov Moscow State University
- N.I. Pirogov Russian National Research Medical University
- I.M. Sechenov Moscow State Medical University
- Issue: Vol 7, No 4 (2012)
- Pages: 11-15
- Section: NEW TRENDS IN MEDICAL SCIENCE
- Published: 23.11.2012
- URL: https://oncohematology.abvpress.ru/ongm/article/view/71
- DOI: https://doi.org/10.17650/1818-8346-2012-7-4-11-15
- ID: 71
Cite item
Full Text
Abstract
Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to their practical medical using. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance for further promoting of either cytoprotective or cytotoxic effects. One of the main effects of fullerenes on living systems is the reactive oxygen species (ROS) formation induction. This lecture provides a modern concept analysis regarding fullerenes effects on ROS formation and modulation of proliferation and apoptosis in normal and tumor cells.
Keywords
About the authors
M. A. Orlova
M.V. Lomonosov Moscow State University
Author for correspondence.
Email: orlova.radiochem@mail.ru
Химический факультет, кафедра радиохимии Russian Federation
T. P. Trofimova
M.V. Lomonosov Moscow State UniversityХимический факультет, кафедра радиохимии Russian Federation
A. P. Orlov
N.I. Pirogov Russian National Research Medical Universityмедико-биологический факультет, кафедра медицинских нанобиотехнологий Russian Federation
O. A. Shatalov
I.M. Sechenov Moscow State Medical Universityфармацевтический факультет, кафедра фармакологии Russian Federation
A. A. Svistunov
I.M. Sechenov Moscow State Medical Universityфармацевтический факультет, кафедра фармакологии Russian Federation
Yu. K. Napolov
I.M. Sechenov Moscow State Medical Universityфармацевтический факультет, кафедра фармакологии Russian Federation
V. P. Chekhonin
N.I. Pirogov Russian National Research Medical Universityмедико-биологический факультет, кафедра медицинских нанобиотехнологий Russian Federation
References
Supplementary files
