Meningeal involvement in chronic lymphocytic leukemia

Abstract

Despite chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia and more than hundred years has passed from the moment of the first description of its clinical picture, the problem on nervous system involvement remains unresolved because of this kind of lesion remains _ very rarely sign of disease. There are less then ten case reports according to literary data. We observed just a one patient with CLL and diagnosed meningeal involvement at the hematologic department of Regional clinical hospital for more than thirty-year period. Clinical and laboratory symptoms were successfully treated by intrathecal administration of cytostatic agents.