Epidemiological and clinical features of lymphoproliferative diseases in the head and neck region

Cover Page

Cite item

Full Text

Abstract

Background. Lymphomas are a heterogeneous group of the lymphoid and hematopoietic system tumors. Neoplastic process often develops in head and neck area, including the integumentary tissues, orbit, nasal cavity, paranasal sinuses, oral cavity, pharynx, salivary glands, thyroid gland, as well as neck lymph nodes. The difficulties of head and neck lymphomas diagnosis are significant, since very often there is a combined non-tumor pathology. The high heterogeneity of lymphomas in the head and neck area requires structuring knowledge about their epidemiology and clinical manifestations.

Objective: to study the epidemiological and clinical features of the head and neck lymphoproliferative diseases, which will lead to an improvement in diagnostic quality of this nosology’s.

Materials and methods. The frequency of head and neck lymphoproliferative diseases detection was estimated based on the study of epicrisis and clinical data of 174 patients hospitalized at the N.N. Blokhin National Medical Research Center of Oncology in the period from 2000 to 2020.

Results. Taking into account the modern clinical and morphological classification of lymphomas of the World Health Organization (2017), information about the features of localization, characteristic signs of extranodal foci and lymph nodes is presented. Detection frequency of various subtypes non-Hodgkin’s and Hodgkin’s lymphomas were determined on a sufficient cohort of patients.

Conclusion. Based on the analysis of clinical and morphological features of head and neck lymphomas, epidemiological and clinical features are described in detail, and differences in the symptoms and clinical manifestations of non-Hodgkin’s and Hodgkin’s lymphomas with a predominant head and neck involvement are revealed.

About the authors

F. Sh. Kamolova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: fazilatdr@yandex.ru
ORCID iD: 0000-0002-6832-9780

Fazilatkhon Sh. Kamolova

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

A. M. Mudunov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-0918-3857

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

P. A. Zeynalova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-1564-424X

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

L. Yu. Grivtsova

A.F. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

ORCID iD: 0000-0001-9103-9688

10 Marshala Zhukova St., Obninsk 249031

Russian Federation

G. F. Allakhverdieva

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0001-5910-5892

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

R. I. Azizyan

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-4046-1894

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

A. A. Akhundov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-9543-990X

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

I. A. Zaderenko

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-0183-4827

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

M. V. Bolotin

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0001-7534-6565

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

D. K. Stelmakh

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-6178-2777

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

V. I. Sokorutov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

K. D. Il’kaev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

V. T. Tsiklauri

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-3090-695X

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

I. M. Gelfand

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-4496-6128

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

M. B. Pak

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0003-4546-0011

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

O. L. Timofeeva

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-6229-7300

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

Yu. E. Ryabukhina

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0001-8443-8816

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

F. M. Abbasbeyli

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-2359-0547

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

Russian Federation

Ts. Chzhao

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0001-8599-5809

24 Kashirskoe Shosse, Moscow 115478

Russian Federation

References

  1. Tumyan G.S., Babicheva L.G., Poddubnaya I.V. Follicular lymphoma. Clinic, diagnostics, treatment. Moscow: Ekon-Inform, 2020. 54 p. (In Russ.).
  2. State of oncological care in Russia in 2019. Eds.: А.D. Kaprin, V.V. Starinskiy, A.O. Shakhzadova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2019. 239 p. (In Russ.).
  3. Kaprin A.D., Savchenko V.G., Poddubnaya I.V. et al. Clinical guidelines. Aggressive non-follicular lymphomas – diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, Burkitt’s lymphoma. Moscow, 2020. 102 p. (In Russ.).
  4. Demina E.A. Guidelines for the treatment of Hodgkin’s lymphoma. Moscow: Gruppa Remedium, 2018. 72 p. (In Russ.).
  5. Poddubnaya I.V., Savchenko V.G. Russian clinical guidelines for the diagnosis and treatment of lymphoproliferative diseases. Moscow: Buki Vedi, 2018. 356 p. (In Russ.).
  6. State of oncological care in Russia in 2016. Eds.: А.D. Kaprin, V.V. Starinskiy, G.V. Petrova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2017. 236 p. (In Russ.).
  7. Wilson L.D., Hinds G.A., Yu J.B. Age, race, sex, stage, and incidence of cutaneous lymphoma. Clin Lymphoma Myeloma Leuk 2012;12(5):291–6. doi: 10.1016/j.clml.2012.06.010.
  8. Tseng C.H., Wang W.C., Chen C.Y. et al. Clinical manifestations of oral lymphomas – retrospective study of 15 cases in a Taiwanese population and a review of 592 cases from the literature. J Form Med Assoc 2021; 120(1–2):361–70. doi: 10.1016/j.jfma.2020.05.025.
  9. Guizard A.V.N., Dejardin O.J., Launay L.C. et al. Diagnosis and management of head and neck cancers in a high-incidence area in France. Medicine 2017;96(26):e7285. doi: 10.1097/MD.0000000000007285.
  10. Dispenza F., Cicero G., Mortellaro G. et al. Primary non-Hodgkins lymphoma of the parotid gland. Braz J Otorhinolaryngol 2011;77(5):639–44. doi: 10.1590/s1808-86942011000500017.
  11. Zhang X.Y., Wang Z.M. Relevance on the diagnosis of malignant lymphoma of the salivary gland. World J Clin Cases 2020;8(13):2717–26. doi: 10.12998/wjcc.v8.i13.2717.
  12. Wu D., Chen C., Zhang M. et al. The clinical features and prognosis of 100 AIDS-related lymphoma cases. Sci Reps 2019;9(1):5381. doi: 10.1038/s41598-019-41869-9.
  13. Syed A.Z., Singer S.R., Mupparapu M. Non-Hodgkin’s lymphoma in the oral cavity. J Mich Dent Assoc 2016;98(4):40–3.
  14. Azarpira N., Ashraf M.J., Khademi B. Non-Hodgkin’s lymphoma of the tongue presenting as an ulcerative lesion. Middl East J Cancer 2011;2(3–4):125–8.
  15. Varun B.R., Varghese N.O., Sivakumar T.T., Joseph A.P. Extranodal non-Hodgkin’s lymphoma of the oral cavity: a case report. Iran J Med Sci 2017;42(4):407–11.
  16. Storck K., Brandstetter M., Keller U. et al. Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med 2019;15(1):1. doi: 10.1186/s13005-018-0186-0.
  17. Babicheva L.G. Modern possibilities of therapy for CD30 + T-cell lymphomas. Moscow, 2020. (In Russ.).
  18. Mudunov A.M., Daykhes N.A., Vinogradov V.V. et al. Tumors of the head and neck in questions and answers. Moscow: FGBU “NMITS onkologii im. N.N. Blokhina” Minzdrava Rossii, 2018. 86 p. (In Russ.).
  19. Iyengar P., Mazloom A., Shihadeh F. et al. Hodgkin lymphoma involving extranodal and nodal head and neck sites: characteristics and outcomes. Cancer 2010;116(16):3825–9. doi: 10.1002/cncr.2513.
  20. Urquhart A., Berg R. Hodgkin’s and nonHodgkin’s lymphoma of the head and neck. Laryngoscope 2001;111(9):1565–9. doi: 10.1097/00005537-20010900000013.
  21. Weber A.L., Rahemtullah A., Ferry J.A. Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimag Clin N Am 2003;13(3):371–92. doi: 10.1016/s1052-5149(03)00039-x.
  22. Simonitsch-Klupp I., Hauser I., Ott G. et al. Diffuse large B-cell lymphomas with plasmablastic/plasmacytoid features are associated with TP53 deletions and poor clinical outcome. Leukemia 2004;18(1):146–55. doi: 10.1038/sj.leu.2403206.
  23. Devi S., Sinha R., Singh R.K. et al. NHL: extranodal T cell lymphoma. Nat J Maxillofac Surg 2015;6(1):99–102. doi: 10.4103/0975-5950.168217.
  24. Swerdlow S.H. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer, 2017. 439 p.
  25. Shankland K.R., Armitage J.O., Hancock B.W. Non-Hodgkin lymphoma. Lancet 2012;380(9844):848–57. doi: 10.1016/S0140-6736(12)60605-9.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c)


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77-36928 от  21.07.2009.