Unspecified skin peripheral T-cell lymphoma: diagnostic difficulties
- Authors: Olisova O.Y.1, Vertieva E.Y.1, Amshinskaya D.R.1, Lecaillon M.G.1, Grekova E.V.1
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Affiliations:
- Department Skin and Venereal Diseases named after V. A. Rakhmanov, Institute of Clinical Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
- Issue: Vol 15, No 3 (2020)
- Pages: 63-66
- Section: DIAGNOSIS AND TREATMENT OF HEMOBLASTOSES
- Published: 15.10.2020
- URL: https://oncohematology.abvpress.ru/ongm/article/view/432
- DOI: https://doi.org/10.17650/1818-8346-2020-15-3-63-66
- ID: 432
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Full Text
Abstract
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) have an aggressive, life-threatening course. 5‑year survival rate is less than 20 %, which may be due to not timely diagnosis. PTCL-NOS can histologically and immunophenotypically mimic other T-cell lymphomas of the skin, including mycosis fungoides. In this connection, the correct diagnosis is most often established in the late stages of the disease. We present a clinical case of PTCL-NOS misdiagnosed as mycosis fungoides.
About the authors
O. Yu. Olisova
Department Skin and Venereal Diseases named after V. A. Rakhmanov, Institute of Clinical Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Author for correspondence.
ORCID iD: 0000-0003-2482-1754
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia Russian Federation
E. Yu. Vertieva
Department Skin and Venereal Diseases named after V. A. Rakhmanov, Institute of Clinical Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
ORCID iD: 0000-0002-1088-2911
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia Russian Federation
D. R. Amshinskaya
Department Skin and Venereal Diseases named after V. A. Rakhmanov, Institute of Clinical Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: dr.jessika@yandex.ru
ORCID iD: 0000-0002-3907-2189
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia Russian Federation
M. G. Lecaillon
Department Skin and Venereal Diseases named after V. A. Rakhmanov, Institute of Clinical Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
ORCID iD: 0000-0003-4767-3002
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia Russian Federation
E. V. Grekova
Department Skin and Venereal Diseases named after V. A. Rakhmanov, Institute of Clinical Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
ORCID iD: 0000-0002-7968-9829
4, Build. 1 Bol’shaya Pirogovskaya St., Moscow 119991, Russia Russian Federation
References
- Doronin V.A. T-cell lymphomas: therapeutic possibilities for a limited choice. Klinicheskaya onkogematologiya. Fundamental’nye issledovaniya i klinicheskaya praktika = Clinical Hematology Oncology. Basic Research and Clinical Practice 2013;6(2):127–38. (In Russ.).
- Tolkachjov S.N., Weenig R.H., Comfere N.I. Cutaneous peripheral T-cell lymphoma, not otherwise specified: a single-center prognostic analysis. J Am Acad Dermatol 2016;75(5):992–9. doi: 10.1016/j.jaad.2016.06.011.
- Singh A., Bhagat M., Siddiqui A.D., Thapa S.S. Peripheral T-cell lymphoma, not otherwise specified: an unusual presentation of a rare lymphoma. Cureus 2019;11(1):e3813. doi: 10.7759/cureus.3813.
- Willemze R., Cerroni L., Kempf W. et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood 2019;133(16):1703–14. doi: 10.1182/blood-2018-11-881268.
- Aderhold K., Carpenter L., Brown K., Donato A. Primary cutaneous peripheral T-cell lymphoma not otherwise specified: a rapidly progressive variant of cutaneous T-cell lymphoma. Case Rep Oncol Med 2015;2015:429068. doi: 10.1155/2015/429068.
- Kempf W., Rozati S., Kerl K. et al. Cutaneous peripheral T-cell lymphomas, unspecified/NOS and rare subtypes: a heterogeneous group of challenging cutaneous lymphomas. G Ital Dermatol Venereol 2012;147(6):553–62.
- Moskowitz A.J., Lunning M.A., Horwitz S.M. How I treat the peripheral T-Cell lymphomas. Blood 2014;123(17):2636–44. doi: 10.1182/Blood-2013-12-516245.
- Dearden C.E., Johnson R., Pettengell R. et al. Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma). Br J Haematol 2011;153(4):451–85. doi: 10.1111/j.1365-2141.2011.08651.x.
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