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MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study)
- Authors: Klimko N.N.1, Khostelidi S.N.1, Shadrivova O.V.1, Bogomolova T.S.1, Avdeenko Y.L.1, Volkova A.G.1, Popova M.O.2, Mihailova I.A.2, Kolbin A.S.3, Boychenko E.G.3, Medvedeva N.V.4, Podoltseva E.I.4, Klimovich A.V.4, Belogurova M.B.4, Zuzgin I.S.5, Uspenskaya O.S.6, Semelev V.N.7, Ponomoreva N.I.8, Abdilova G.K.9, Zuborovskaya L.S.2, Afanasiev B.V.2
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Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- I.P. Pavlov First Saint Petersburg State Medical University
- Children City Hospital No 1
- City Clinical Hospital No 31
- N.N. Petrov Research Institute of Oncology
- Leningrad Regional Clinical Hospital
- S.M. Kirov Military Medical Academy
- Russian Children Clinical Hospital
- Republican State Fiscal Organization Scientific Center of Pediatrics and Pediatric Surgery
- Issue: Vol 12, No 2 (2017)
- Pages: 14-22
- Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
- Published: 27.06.2017
- URL: https://oncohematology.abvpress.ru/ongm/article/view/237
- DOI: https://doi.org/10.17650/1818-8346-2017-12-2-14-22
- ID: 237
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Abstract
In 2004–2016 we prospectively observed 59 oncohematology patients with mucormycosis; 21 children and 38 adults. The most frequent underlying diseases were acute myeloid leukemia and acute lymphoblastic leukemia (64 %); and main risk factors were сytostatic chemotherapy and allogeneic HSCT with prolonged (median – 30 days) neutropenia and lymphocytopenia. The etiology agents were Rhizopus spp. (47 %); Rhizomucor spp. (28 %); Lichtheimia corуmbifera (17 %) and Mucor spp. (8 %). Lichtheimia corуmbifera was found more often in children; Rhizopus and Mucor spp. in adults. Pulmonary mucormycosis was main clinical form (73 %); and ≥2 organs involvement was noted in 44 % patients. Antifungal therapy was used in 78 % patients; surgery – in 47 %. In treated with antifungals patients 12 weeks overall survival was 59 %. The positive prognostic factors were remission of underlying disease and combination antifungal therapy.
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About the authors
N. N. Klimko
North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: n_klimko@mail.ru
41 Kirochnaya St.; Saint Petersburg; 191015 Russian Federation
S. N. Khostelidi
North-Western State Medical University named after I.I. Mechnikov41 Kirochnaya St.; Saint Petersburg; 191015 Russian Federation
O. V. Shadrivova
North-Western State Medical University named after I.I. Mechnikov41 Kirochnaya St.; Saint Petersburg; 191015 Russian Federation
T. S. Bogomolova
North-Western State Medical University named after I.I. Mechnikov41 Kirochnaya St.; Saint Petersburg; 191015 Russian Federation
Y. L. Avdeenko
North-Western State Medical University named after I.I. Mechnikov41 Kirochnaya St.; Saint Petersburg; 191015 Russian Federation
A. G. Volkova
North-Western State Medical University named after I.I. Mechnikov41 Kirochnaya St.; Saint Petersburg; 191015 Russian Federation
M. O. Popova
I.P. Pavlov First Saint Petersburg State Medical University6–8 L’va Tolstogo St.;Saint Petersburg 197022 Russian Federation
I. A. Mihailova
I.P. Pavlov First Saint Petersburg State Medical University6–8 L’va Tolstogo St.;Saint Petersburg 197022 Russian Federation
A. S. Kolbin
Children City Hospital No 114 Avangardnaya St.; Saint Petersburg; 198205 Russian Federation
E. G. Boychenko
Children City Hospital No 114 Avangardnaya St.; Saint Petersburg; 198205 Russian Federation
N. V. Medvedeva
City Clinical Hospital No 313 Dinamo St.; St. Petersburg; 197110 Russian Federation
E. I. Podoltseva
City Clinical Hospital No 313 Dinamo St.; St. Petersburg; 197110 Russian Federation
A. V. Klimovich
City Clinical Hospital No 313 Dinamo St.; St. Petersburg; 197110 Russian Federation
M. B. Belogurova
City Clinical Hospital No 313 Dinamo St.; St. Petersburg; 197110 Russian Federation
I. S. Zuzgin
N.N. Petrov Research Institute of Oncology68; Leningradskaya St.; Pesochnyi Settlement; Saint Petersburg 197758 Russian Federation
O. S. Uspenskaya
Leningrad Regional Clinical HospitalSt. Petersburg; 45–49 Lunacharskogo Prosp.; St. Petersburg; 194291 Russian Federation
V. N. Semelev
S.M. Kirov Military Medical Academy6 Akademika Lebedeva St.; Saint Petersburg 194044 Russian Federation
N. I. Ponomoreva
Russian Children Clinical Hospital117 Leninskiy Prospect; Moscow; 119571 Russian Federation
G. K. Abdilova
Republican State Fiscal Organization Scientific Center of Pediatrics and Pediatric Surgery146; Al’-Farbi str.; Almaty; Kazakhstan; 050040 Kazakhstan
L. S. Zuborovskaya
I.P. Pavlov First Saint Petersburg State Medical University6–8 L’va Tolstogo St.;Saint Petersburg 197022 Russian Federation
B. V. Afanasiev
I.P. Pavlov First Saint Petersburg State Medical University6–8 L’va Tolstogo St.;Saint Petersburg 197022 Russian Federation
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