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Application experience of extracorporeal photopheresis for treatment of acute “graft-versus-host” disease after allogeneic hematopoietic stem cell transplantation
- Authors: Kozlov A.V.1, Bykova T.A.1, Kulagina I.I.1, Bondarenko S.N.1, Semenova E.V.1, Zubarovskaya l.S.1, Afanasyev B.V.1
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Affiliations:
- Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of Russia
- Issue: Vol 8, No 3 (2013)
- Pages: 27-34
- Section: HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Published: 21.08.2013
- URL: https://oncohematology.abvpress.ru/ongm/article/view/23
- DOI: https://doi.org/10.17650/1818-8346-2013-8-3-27-34
- ID: 23
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Abstract
Extracorporeal photopheresis (ECP) has been used as a component of combined immunosuppressive therapy in 53 patients with steroid-refractory
acute “graft-versus-host” disease. Overall response was observed in 35 patients (66 %; 95 % CI 52.6–77.3): complete response (CR) in 15 pts (28.3 %; 95 % CI 18–41.6) and partial response (PR) in 20 pts (37.7 %; 95 % CI 25.9–51.2). 3-year OS was 39 % in patients with clinical response (CR or PR); in the absence of clinical response OS was 8 % during the first year (p < 0.0001). Median methylprednisolone dose before ECP was 2 mg/kg/day, and at the end of ECP course – 0.7 mg/kg/day (p < 0.0001).
About the authors
A. V. Kozlov
Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of Russia
Author for correspondence.
Russian Federation
T. A. Bykova
Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of RussiaRussian Federation
I. I. Kulagina
Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of RussiaRussian Federation
S. N. Bondarenko
Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of RussiaRussian Federation
E. V. Semenova
Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of RussiaRussian Federation
l. S. Zubarovskaya
Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of RussiaRussian Federation
B. V. Afanasyev
Raisa Gorbacheva Memorial Institute of Children Hematology and Transplantation, First Pavlov Saint Petersburg State Medical University, Ministry of Health of RussiaRussian Federation
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