Primary diffuse large B-cell lymphoma of the central nervous system (case report and literature review)

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Abstract

The central nervous system (CNS) involvement in patients with non-Hodgkin’s lymphomas is not uncommon, especially in children with mature B-cells lymphomas, unlike the primary CNS lymphoma (PCNSL). PCNSL is a rare extranodal form of NHL that occurs only in the CNS – in the brain, spinal cord, meninges, in the eyes, and not extending beyond CNS. Its frequency in adults is 1–2 % of lymphomas and 5 % of all CNS tumors. Data on prevalence in childhood are not available, limited to some case reports. This article presents a literature review about PCNSL diagnosis and treatment and case report of such lymphoma with intraspinal lesion in 11 years old child.

About the authors

K. A. Komratova

National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;

1 Samory Mashela St., Moscow 117997, Russia Russian Federation

Yu. G. Abugova

National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;

Author for correspondence.
Email: Yuliya.Abugova@fccho-moscow.ru
1 Samory Mashela St., Moscow 117997, Russia Russian Federation

S. S. Ozerov

National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;

1 Samory Mashela St., Moscow 117997, Russia Russian Federation

D. S. Abramov

National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;

1 Samory Mashela St., Moscow 117997, Russia Russian Federation

G. V. Tereshchenko

National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;

1 Samory Mashela St., Moscow 117997, Russia Russian Federation

N. V. Myakova

National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunnology named after Dmitry Rogachev, Ministry of Health of Russia;

1 Samory Mashela St., Moscow 117997, Russia Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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