MYELODYSPLASTIC/MYELOPROLIFERATIVE DISEASES

I. N. Subortseva; Суборцева И. Н.; A. I. Melikyan; Меликян А. Л.

doi:10.17650/1818-8346-2016-11-4-8-17

MYELODYSPLASTIC/MYELOPROLIFERATIVE DISEASES

Authors: Subortseva I.N.¹, Melikyan A.I.¹
Affiliations:
1. Hematological Research Center
Issue: Vol 11, No 4 (2016)
Pages: 8-17
Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
Published: 03.12.2016
URL: https://oncohematology.abvpress.ru/ongm/article/view/211
DOI: https://doi.org/10.17650/1818-8346-2016-11-4-8-17
ID: 211

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Abstract

Chronic myeloid malignancies that have characteristics of both the myelodysplastic and myeloproliferative disorders allocated to myelodysplastic/myeloproliferative diseases (MDS/MPD) group in 2008 World Health Organization classification. This group includes chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, atypical chronic myeloid leukemia, refractory anemia with ringed sideroblasts and thrombocytosis (RARS-T) and unclassified MDS/MPD. Except RARS-T diseases in this group have similar molecular characteristics and clinical manifestations, which require the study of biology, specific molecular markers, morphological features and a clearer definition of nosology. This review provides information on international guidelines for the diagnosis and treatment of MDS/MPD.