Genetic heterogeneity of infant acute leukemias

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  • Authors: Tsaur G.A.1,2,3,4, Fleischman E.W.5,6, Popov A.M.7,8, Fechina L.G.1,9, Rumyantsev S.A.7,10,11
  • Affiliations:
    1. Regional Children Clinical Hospital No 1
    2. 32 S. Deryabinoy St., Ekaterinburg, 620149, Russia Institute of Medical Cell Technologies
    3. 22a Karla Marksa St., Ekaterinburg, 620026, Russia Ural Federal University named after the first President of Russia B. N. Yel’tsin
    4. 19 Mira St., Ekaterinburg, 620002, Russia
    5. N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
    6. 23 Kashirskoe Shosse, Moscow, 115478, Russia
    7. Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia
    8. 1 Samory Mashela St., Moscow, 117998, Russia
    9. 32 S. Deryabinoy St., Ekaterinburg, 620149, Russia
    10. 1 Samory Mashela St., Moscow, 117998, Russia N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
    11. 1 Ostrovityanova St., Moscow, 117997, Russia
  • Issue: Vol 11, No 1 (2016)
  • Pages: 14-23
  • Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
  • Published: 31.03.2016
  • URL: https://oncohematology.abvpress.ru/ongm/article/view/177
  • DOI: https://doi.org/10.17650/1818-8346-2016-11-1-14-23
  • ID: 177

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Abstract

In this review we present current state of cytogenetic and molecular genetic diagnostics of various aberrations in infant acute leukemias together with our own experience in this field. A complex characteristic of acute leukemias was performed for both MLL-positive and MLL-negative patients. Genetic heterogeneity was shown. Common and rare cytogenetic and molecular genetic aberrations were presented.

About the authors

G. A. Tsaur

Regional Children Clinical Hospital No 1; 32 S. Deryabinoy St., Ekaterinburg, 620149, Russia

Institute of Medical Cell Technologies; 22a Karla Marksa St., Ekaterinburg, 620026, Russia

Ural Federal University named after the first President of Russia B. N. Yel’tsin; 19 Mira St., Ekaterinburg, 620002, Russia

Author for correspondence.
Email: tsaur@mail.ru
Russian Federation

E. W. Fleischman

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia

Russian Federation

A. M. Popov

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117998, Russia

Russian Federation

L. G. Fechina

Regional Children Clinical Hospital No 1; 32 S. Deryabinoy St., Ekaterinburg, 620149, Russia

Russian Federation

S. A. Rumyantsev

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia; 1 Samory Mashela St., Moscow, 117998, Russia

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; 1 Ostrovityanova St., Moscow, 117997, Russia

Russian Federation

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