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Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation
- Authors: Lipets E.N.1,2, Ataullakhanov F.I.1,2,3,4, Panteleev M.A.1,2,3,4
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Affiliations:
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev
- Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences
- HemaCore Company
- M.V. Lomonosov Moscow State University
- Issue: Vol 10, No 3 (2015)
- Pages: 73-77
- Section: BASIC RESEARCH
- Published: 08.10.2015
- URL: https://oncohematology.abvpress.ru/ongm/article/view/157
- DOI: https://doi.org/10.17650/1818-8346-2015-10-3-10-25
- ID: 157
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Abstract
Thrombosis is a fatal hemostatic disorders occurring in various conditions ranging from pregnancy and surgery to cancer, sepsis and heart attack. Despite the availability of different anticoagulants and accumulated clinical experience, proving their effectiveness, thrombosis remains a major cause of morbidity and mortality. This is largely due to the fact that conventional laboratory coagulation tests are not sufficiently sensitive to the hypercoagulable state, and they are difficult to use for assessing the risk of thrombosis. Specific molecular markers (D-dimers, fibrinopeptide, thrombin-antithrombin complex) are more effective, but also have a large number of disadvantages. A possible solution is the use of integrated test, which simulate in vitro the majority of the physiological coagulation processes. In the first part of this paper the biochemical processes that cause the risk of thrombosis were discussed.
About the authors
E. N. Lipets
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev;Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences
1 Samory Mashela St., Moscow, 117997;
4 Kosygina St., Moscow, 119991
Russian FederationF. I. Ataullakhanov
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev;Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences;
HemaCore Company;
M.V. Lomonosov Moscow State University
1 Samory Mashela St., Moscow, 117997;
4 Kosygina St., Moscow, 119991;
4th 8 Marta St., Moscow, 125319;
1 Lеninskie gory St., Moscow, 119991
Russian FederationM. A. Panteleev
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev;Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences;
HemaCore Company;
M.V. Lomonosov Moscow State University
Author for correspondence.
Email: mapanteleev@yandex.ru
1 Samory Mashela St., Moscow, 117997;
4 Kosygina St., Moscow, 119991;
4th 8 Marta St., Moscow, 125319;
1 Lеninskie gory St., Moscow, 119991
Russian FederationReferences
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