Monitoring of patients with hematological malignancies after anticancer therapy

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Abstract

The number of patients achieved continuous complete remission constantly increasing as a result of pediatric hematology development. Improvement and optimization of treatment protocols includes both efficacy increase and toxicity reduction, but today any type therapy is associated with risk of long-term adverse effects.
Children and adolescents who have received anticancer treatment – is a special cohort whose health requires a special observation. This
monitoring program should be aimed at both remission control and early detection of possible treatment long-term side effects. Some side effects have long (five, ten or more years) latent period and observation of such patients should be carried out for a long time, respectively. This article provides a brief overview of international recommendations for monitoring children and adolescents after anticancer therapy, analyzed the situation with follow-up in Russia, and offers the variant of follow-up service organization in the clinic, based on the own experience. The article also considers issues about relapse and secondary tumors diagnosis. Using international recommendations the main side effects of chemo- and radiation therapy systematized. In conclusion, an example of a monitoring program designed for the individual patient, based on age, gender, previous disease and treatment is shown.

About the authors

A. E. Rudneva

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198

Author for correspondence.
Email: Anastasija.Rudneva@fccho-moscow.ru
Russian Federation

E. E. Ilyina

Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198

Russian Federation

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